{"id":"W4407913631","doi":"10.1128/mbio.00328-25","title":"The HOPS and vCLAMP protein Vam6 connects polyphosphate with mitochondrial function and oxidative stress resistance in <i>Cryptococcus neoformans</i>","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Chung-Ang University","keywords":"Cryptococcus neoformans; Vacuole; Endomembrane system; Biology; Cell biology; Polyphosphate; Mitochondrion; Alternative oxidase; Microbiology; Biochemistry; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007574934,0.0001012929,0.0001514007,0.00004729106,0.00026257,0.00004006846,0.00002134388,0.00004288357,0.000003030992],"category_scores_gemma":[0.00005117812,0.00006106439,0.00001338292,0.0001990377,0.0001489662,0.00006469368,0.00003078161,0.0001414847,0.000001054452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003008455,"about_ca_system_score_gemma":0.00003837088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001482022,"about_ca_topic_score_gemma":0.003518326,"domain_scores_codex":[0.9994478,0.000026169,0.0001227613,0.0001725697,0.0000745117,0.0001562235],"domain_scores_gemma":[0.9996768,0.00008125605,0.00003790899,0.0001200022,0.00005343991,0.00003057187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0318728,0.001055079,0.5809767,0.001818665,0.001685202,0.0001613601,0.009849676,0.00002040085,0.1760566,0.1472323,0.02167768,0.02759362],"study_design_scores_gemma":[0.01349336,0.002125739,0.8270051,0.002259641,0.0002456936,0.00001098038,0.00407065,0.00006227987,0.06027096,0.006076446,0.08392044,0.0004586491],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881904,0.003393109,0.0002621637,0.001760714,0.0001730431,0.001041417,0.000008195938,0.00002812405,0.005142882],"genre_scores_gemma":[0.9949742,0.000190925,0.0001857197,0.0001695478,0.00004833199,0.0001913696,0.000003528721,0.000006252383,0.004230122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2460285,"threshold_uncertainty_score":0.2490133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004607902465842605,"score_gpt":0.220178391376875,"score_spread":0.2155704889110324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}