{"id":"W4407920046","doi":"10.1128/msphere.01037-24","title":"Exploring the differential localization of protein kinase A isoforms in <i>Candida albicans</i>","year":2025,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Filamentation; Cytosol; Protein subunit; Protein kinase A; Biology; Candida albicans; Cytoplasm; Cell biology; Gene isoform; Biochemistry; Subcellular localization; Kinase; Gene; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102765,0.0000760878,0.0001764495,0.00002683494,0.00004302006,0.000007083765,0.00006707721,0.00003326947,0.0002170768],"category_scores_gemma":[0.00009239393,0.00004682426,0.0000557531,0.0003085855,0.00007364359,0.00006339448,0.00002830829,0.0001190131,0.000003553522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005065222,"about_ca_system_score_gemma":0.00008593038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004010614,"about_ca_topic_score_gemma":0.001385647,"domain_scores_codex":[0.999335,0.00002941901,0.0002171795,0.0001397189,0.0001435741,0.000135131],"domain_scores_gemma":[0.9996254,0.00002485905,0.00003535591,0.0002440854,0.00004541007,0.00002489686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001894649,0.0006870396,0.7946424,0.001543557,0.00008287671,0.0000319333,0.0014585,0.0000868166,0.0533255,0.004147729,0.0006549887,0.141444],"study_design_scores_gemma":[0.002827196,0.0002420532,0.9112729,0.002195595,0.00008101925,0.000001134869,0.0029982,0.001674302,0.07129838,0.001265573,0.005961857,0.0001817872],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892228,0.0002291809,0.005171429,0.0003878339,0.00006230604,0.0004514942,0.000002375449,0.00001620472,0.004456391],"genre_scores_gemma":[0.9977105,0.00004192628,0.00003709799,0.0001281,0.00002358445,0.00006460745,0.000004625485,0.000005797805,0.00198376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1412622,"threshold_uncertainty_score":0.2376838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02935694493078373,"score_gpt":0.2655244168716001,"score_spread":0.2361674719408163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}