{"id":"W4407923655","doi":"10.3390/genes16030269","title":"An RB1CC1 Missense Variant in Nova Scotia Duck Tolling Retrievers with Degenerative Encephalopathy","year":2025,"lang":"en","type":"article","venue":"Genes","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Nova scotia; Missense mutation; Biology; Genetics; Genotyping; Pathology; Genotype; Medicine; Gene; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102924,0.0001531385,0.0001848519,0.0001063705,0.00008728569,0.00006344658,0.0002169906,0.00005337131,0.00006103408],"category_scores_gemma":[0.0002058293,0.0001134798,0.00003757106,0.0006726258,0.0001031578,0.0001453102,0.00004078864,0.0001205599,0.00002126549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001408248,"about_ca_system_score_gemma":0.0001080845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000128228,"about_ca_topic_score_gemma":0.0001880963,"domain_scores_codex":[0.9986385,0.0001734976,0.0001719411,0.0005543293,0.0001661757,0.0002956118],"domain_scores_gemma":[0.9994562,0.00008425416,0.00004513542,0.000269557,0.00003491335,0.0001099161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004135574,0.0002550874,0.004771651,0.00001651104,0.000004530218,0.00208125,0.0002562607,0.002123139,0.9779121,0.008598992,0.0001294059,0.00343746],"study_design_scores_gemma":[0.001468251,0.0004035517,0.04358471,0.00005472639,0.00005077317,0.0001112602,0.0002610277,0.001951855,0.945877,0.001626518,0.004135603,0.0004747889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968307,0.0004584237,0.0005588884,0.0003867954,0.0004228403,0.0002240823,0.00001726513,0.00005124857,0.001049741],"genre_scores_gemma":[0.9959281,0.0001025282,0.0005277463,0.003096763,0.0000615417,0.000005884252,0.000002025052,0.000009102161,0.000266289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03881306,"threshold_uncertainty_score":0.4627572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02475439241325365,"score_gpt":0.2821735891338557,"score_spread":0.257419196720602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}