{"id":"W4407926725","doi":"10.1016/j.bpj.2025.02.015","title":"Ergosterol depletion by fish AMP analogs likely enhances fungal membrane permeability","year":2025,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Alliance de recherche numérique du Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Ergosterol; Fish <Actinopterygii>; Membrane permeability; Chemistry; Membrane; Permeability (electromagnetism); Biophysics; Zoology; Biology; Biochemistry; Fishery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722754,0.0001408527,0.0001696739,0.00003853101,0.0001550996,0.00008236664,0.0001867168,0.000110233,0.00003552129],"category_scores_gemma":[0.00009961349,0.0001198288,0.0001794945,0.000158191,0.00009049617,0.00001269478,0.00006091477,0.0001539465,0.00001115004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002742119,"about_ca_system_score_gemma":0.00005783917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006971406,"about_ca_topic_score_gemma":0.00001828562,"domain_scores_codex":[0.9989876,0.0001012248,0.0002653462,0.0002880673,0.0001579966,0.0001997431],"domain_scores_gemma":[0.9994225,0.0000140226,0.0001015568,0.0002281256,0.0001467028,0.00008707331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007810521,0.0001562954,0.000964266,0.00001461943,0.00005745428,7.168088e-7,0.00001012804,0.00001091694,0.9834792,0.00001995799,0.01370282,0.001505521],"study_design_scores_gemma":[0.0003504459,0.0001636139,0.008323068,0.00001694502,0.00004158422,0.0000115198,0.00001632169,0.0000692612,0.9652451,0.00002871634,0.02559859,0.0001348369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928991,0.0001235582,0.005840559,0.0004485955,0.0002246903,0.00007936641,0.00002709858,0.000009391533,0.0003476614],"genre_scores_gemma":[0.9974468,0.0002894298,0.00007990431,0.0006778407,0.0003707444,0.000008283448,0.0002123288,0.000009332051,0.0009052992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0182341,"threshold_uncertainty_score":0.4886475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007046651888689486,"score_gpt":0.2497691797808755,"score_spread":0.242722527892186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}