{"id":"W4407931963","doi":"10.1101/2025.02.25.640129","title":"Ketogenic interventions prevent alterations of the gut microbiome in transgenic Alzheimer’s Disease mice","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Diet and metabolism studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Université de Sherbrooke","funders":"","keywords":"Genetically modified mouse; Microbiome; Transgene; Gut microbiome; Disease; Alzheimer's disease; Ketogenic diet; Psychological intervention; Neuroscience; Biology; Medicine; Bioinformatics; Genetics; Internal medicine; Epilepsy; Psychiatry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003693834,0.0006983731,0.0006025152,0.0008397347,0.0003312158,0.000571518,0.0003399915,0.0006316918,0.002761911],"category_scores_gemma":[0.0002062556,0.0002961194,0.0005637188,0.0003110509,0.0004953874,0.0003622311,0.0004214089,0.00130312,0.0005895908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003553075,"about_ca_system_score_gemma":0.0003524765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007057,"about_ca_topic_score_gemma":0.001529813,"domain_scores_codex":[0.9997228,0.00003969771,0.00003954799,0.00007009338,0.00005966042,0.00006815039],"domain_scores_gemma":[0.9996254,0.00003571998,0.0001318403,0.00004039799,0.00003818295,0.0001285219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001465825,0.0002621044,0.0005354999,0.00007850595,0.00003023054,0.0001112291,0.00005386766,0.00006123854,0.9943335,0.0001650375,0.0002068721,0.002696208],"study_design_scores_gemma":[0.0003697013,0.00251004,0.02001096,0.00006568403,0.0001749809,0.0004982596,0.000262682,0.0009524597,0.9658319,0.0004357143,0.008855919,0.000031696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991234,0.001291228,0.002802756,0.0004541163,0.0001670627,0.00006800531,0.002357714,0.0002468434,0.001378247],"genre_scores_gemma":[0.9772264,0.002500275,0.00733839,0.0005150732,0.00008534067,0.0002942657,0.002556568,0.0002204668,0.009263126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002761911,"threshold_uncertainty_score":0.009239495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03113021631055145,"score_gpt":0.2823213274629162,"score_spread":0.2511911111523647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}