{"id":"W4407932539","doi":"10.1101/2025.02.20.639313","title":"Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Brain and Behavior Research Foundation","keywords":"Dopamine; Transcriptome; Neuroscience; Biology; Neuroplasticity; Regulator; Transcription factor; Gene knockdown; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009824891,0.0001578003,0.0001648883,0.0001286539,0.0001385356,0.0002549899,0.000100544,0.000176102,0.0007016597],"category_scores_gemma":[0.0001394276,0.000120153,0.0001639039,0.0001177691,0.0002118613,0.0001316871,0.0002481236,0.000419133,0.0002288588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001837707,"about_ca_system_score_gemma":0.0001960831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004833653,"about_ca_topic_score_gemma":0.001023547,"domain_scores_codex":[0.9999008,0.000008540618,0.000003846248,0.00004073075,0.00002197102,0.00002412193],"domain_scores_gemma":[0.9999377,0.000008724816,0.00002140119,0.00001100017,0.000008753444,0.00001242392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009978508,0.000006946402,0.003505536,0.00003711341,0.00001317475,0.0001105901,0.00006149081,0.00004207193,0.988908,0.0001561911,0.0001267046,0.006932425],"study_design_scores_gemma":[0.00001222627,0.0003289021,0.6446371,0.00003540143,0.00005332356,0.001610158,0.0003755418,0.001138466,0.3433429,0.0007908719,0.007653104,0.00002203468],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822237,0.004846609,0.008103901,0.0003157542,0.00008573857,0.00002178201,0.001933286,0.0001257924,0.002343475],"genre_scores_gemma":[0.9905027,0.002216364,0.002598552,0.0001825284,0.00002241128,0.0000446297,0.001611008,0.00003180407,0.002789915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007016597,"threshold_uncertainty_score":0.002347291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521098039854918,"score_gpt":0.2240539038983408,"score_spread":0.2088429234997916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}