{"id":"W4407934175","doi":"10.1016/j.brs.2024.12.857","title":"The Safety, Clinical, and Neurophysiological Effects of Intranasal Ketamine in Patients Who Do Not Respond to Electroconvulsive Therapy (SURE-Trial). Protocol for a Pilot, Open-Label Clinical Trial","year":2025,"lang":"en","type":"article","venue":"Brain stimulation","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University","funders":"","keywords":"Ketamine; Electroconvulsive therapy; Medicine; Clinical trial; Nasal administration; Protocol (science); Open label; Anesthesia; Neurophysiology; Pharmacology; Psychiatry; Internal medicine; Electroconvulsive Shock; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01220837,0.004706027,0.005917001,0.001056207,0.00217744,0.001967297,0.002908788,0.005312427,0.04579858],"category_scores_gemma":[0.01240723,0.001836523,0.002539509,0.0009867431,0.002851712,0.002826129,0.001329829,0.006029786,0.01399845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002397091,"about_ca_system_score_gemma":0.008371973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001040351,"about_ca_topic_score_gemma":0.002266,"domain_scores_codex":[0.9953738,0.002205336,0.0005472438,0.0006629477,0.0005444482,0.0006663225],"domain_scores_gemma":[0.9928853,0.001115656,0.00146383,0.001162791,0.001553342,0.001819066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9332481,0.03124317,0.0007814056,0.003203103,0.0004524814,0.000232628,0.0001687639,0.0007957896,0.004077846,0.0007654519,0.007825858,0.01720548],"study_design_scores_gemma":[0.8626879,0.1209024,0.002717146,0.0004347211,0.0002252975,0.00009754011,0.00007818591,0.000564271,0.0009631088,0.000762668,0.01050396,0.00006279294],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02262338,0.0003767865,0.001313085,0.0003967185,0.0003495296,0.9700184,0.002380232,0.0001354693,0.002406383],"genre_scores_gemma":[0.02624037,0.0002832563,0.00292163,0.0007519667,0.0001805897,0.9669562,0.001026627,0.00001730934,0.001622034],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04579858,"threshold_uncertainty_score":0.1532115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1038043861683772,"score_gpt":0.4791972694670505,"score_spread":0.3753928832986734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}