{"id":"W4407934451","doi":"10.1016/j.brs.2024.12.951","title":"Connectivity-guided, interleaved iTBS-fMRI demonstrates subcortical target engagement in treatment-resistant depression","year":2025,"lang":"en","type":"article","venue":"Brain stimulation","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Centre for Addiction and Mental Health; Sunnybrook Health Science Centre","funders":"","keywords":"Depression (economics); Psychology; Neuroscience; Treatment-resistant depression; Major depressive disorder; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.000491587,0.000268098,0.0003140042,0.0003469524,0.0003361363,0.00007905394,0.0001411147,0.0001035716,0.00007395195],"category_scores_gemma":[0.01282364,0.0002451501,0.00009730359,0.0006038551,0.0001273089,0.0002932589,0.0001277332,0.0001931032,0.00003507229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004525881,"about_ca_system_score_gemma":0.0001079546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001064465,"about_ca_topic_score_gemma":0.0002108379,"domain_scores_codex":[0.9975172,0.0006254585,0.0004335987,0.0007780694,0.0002867921,0.0003588673],"domain_scores_gemma":[0.9876074,0.01187443,0.00009906916,0.0003032055,0.00005741951,0.00005847576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001534432,0.001344422,0.3371079,0.00008178405,0.00007763883,0.0001030293,0.000845094,0.03322558,0.5778618,0.02366561,0.007304458,0.01684825],"study_design_scores_gemma":[0.005722926,0.0005304284,0.5802114,0.0002317641,0.00005095039,0.00000948153,0.0003225348,0.1316492,0.2574686,0.01516023,0.008044667,0.0005978461],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758446,0.0001008577,0.01050044,0.006548149,0.0004509752,0.0008548416,0.00001720809,0.0001856697,0.00549729],"genre_scores_gemma":[0.9971299,0.00001214173,0.0005097564,0.001469421,0.00005291047,0.0001365148,0.00001195055,0.00001784017,0.0006595611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3203932,"threshold_uncertainty_score":0.999693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05417414270792288,"score_gpt":0.3280574570833825,"score_spread":0.2738833143754597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}