{"id":"W4407935048","doi":"10.1016/j.brs.2024.12.095","title":"Dosing considerations with the partial NMDA receptor agonist D-cycloserine as an adjuvant to intermittent theta-burst stimulation for major depressive disorder","year":2025,"lang":"en","type":"article","venue":"Brain stimulation","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"NMDA receptor; Partial agonist; Agonist; Stimulation; Dosing; Medicine; Cycloserine; Neuroscience; Pharmacology; Major depressive disorder; Psychology; Receptor; Internal medicine; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002066283,0.0002663058,0.0003059211,0.0001585412,0.0005891172,0.0001337225,0.00008404777,0.0001019052,0.0001267453],"category_scores_gemma":[0.000536254,0.0001744155,0.00009289065,0.0002179051,0.00007738203,0.0002568977,0.00005724279,0.0001302025,0.00002060652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001438877,"about_ca_system_score_gemma":0.0001690027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001113683,"about_ca_topic_score_gemma":0.0002291295,"domain_scores_codex":[0.9984376,0.0001283794,0.0003606245,0.0004988976,0.0003078899,0.0002665419],"domain_scores_gemma":[0.9982928,0.0007066947,0.0001571141,0.0004473576,0.000266537,0.0001294821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.02552159,0.004206742,0.1874177,0.0005247414,0.001754842,0.00004344725,0.008457403,0.3476948,0.1474868,0.01651386,0.03472394,0.2256541],"study_design_scores_gemma":[0.02410471,0.00332504,0.8250696,0.001046846,0.00117738,0.00002938871,0.0008481794,0.09638523,0.02074858,0.00285393,0.02367436,0.0007367208],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9139104,0.00008119556,0.05696746,0.02455186,0.0001981564,0.003635515,0.00004381968,0.0001598984,0.0004516839],"genre_scores_gemma":[0.9903343,0.000001777738,0.005244545,0.001568002,0.0001934289,0.0003530589,0.000486419,0.0000422039,0.001776299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6376519,"threshold_uncertainty_score":0.7112456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01985201663183662,"score_gpt":0.3247793862251478,"score_spread":0.3049273695933112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}