{"id":"W4407935714","doi":"10.1021/acs.jmedchem.4c02605","title":"New Synthesis and Pharmacological Evaluation of Enantiomerically Pure (<i>R</i>)- and (<i>S</i>)-Methadone Metabolites as <i>N</i>-Methyl-<scp>d</scp>-aspartate Receptor Antagonists","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Stereochemistry; Methadone; Receptor; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016432,0.0003059125,0.0002169528,0.0001708759,0.0001256368,0.0001939152,0.0002741244,0.0001963146,0.001564134],"category_scores_gemma":[0.0001296706,0.0001024537,0.000202651,0.0001456435,0.0001136859,0.0002604865,0.0001710407,0.0002997192,0.0003832337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613591,"about_ca_system_score_gemma":0.0002934867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000395525,"about_ca_topic_score_gemma":0.0009096564,"domain_scores_codex":[0.9999256,0.0000138302,0.00000959054,0.00001472195,0.00002079379,0.00001553615],"domain_scores_gemma":[0.9999522,0.000003494088,0.00001416637,0.000007671019,0.00001133647,0.00001110116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001557049,0.00009506773,0.00009117323,0.0001160388,0.00001194999,0.0001871847,0.00003654552,0.0002467094,0.9874956,0.0005493939,0.0001934508,0.01082111],"study_design_scores_gemma":[0.00005358239,0.00144086,0.0006365015,0.00001265374,0.00002907196,0.0003937692,0.00002147405,0.0007933493,0.988996,0.0001011041,0.007508859,0.00001270302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.95202,0.006771161,0.02083199,0.0002818843,0.0000861505,0.0003895538,0.001630861,0.0002307482,0.01775762],"genre_scores_gemma":[0.9701545,0.00687666,0.01723798,0.0001667435,0.00003800382,0.000108186,0.0009006319,0.00004936254,0.004467856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564134,"threshold_uncertainty_score":0.005232573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03627503992742778,"score_gpt":0.3609352213080874,"score_spread":0.3246601813806596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}