{"id":"W4407946625","doi":"10.1212/nxg.0000000000200251","title":"Association of <i>DMD</i> Gene Variant Classes With Motor Outcomes in a Drug Registration Clinical Trial Setting","year":2025,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Duchenne muscular dystrophy; Dystrophin; Medicine; Clinical trial; Null allele; Biology; Gene; Bioinformatics; Genetics; Internal medicine; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01744342,0.0002886059,0.0008676291,0.0004962384,0.0005520612,0.001515653,0.000614476,0.0008744098,0.002963855],"category_scores_gemma":[0.02697935,0.0001901323,0.0009731659,0.0008918377,0.0006815465,0.0006137105,0.0006290834,0.0008188402,0.000359411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005318049,"about_ca_system_score_gemma":0.0008299312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004322118,"about_ca_topic_score_gemma":0.000909513,"domain_scores_codex":[0.9765798,0.01670922,0.002579218,0.002095206,0.0013783,0.0006582662],"domain_scores_gemma":[0.9624667,0.01509293,0.01826116,0.001742537,0.00121872,0.001217945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.13186,0.001065481,0.8351622,0.0007450842,0.003957373,0.0002641176,0.0002245587,0.0005633735,0.003747952,0.0006304498,0.00166991,0.02010948],"study_design_scores_gemma":[0.01303432,0.02502613,0.9458335,0.0002378382,0.004271911,0.001201029,0.0003112302,0.002744337,0.002670509,0.001008144,0.003585515,0.0000755057],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931972,0.001905035,0.0009157202,0.00040695,0.00003117,0.0004325492,0.00112651,0.00002136437,0.001963556],"genre_scores_gemma":[0.998234,0.0001044166,0.000584956,0.00020669,0.00003029002,0.0002538434,0.0004314285,0.000007554228,0.0001467665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01744342,"threshold_uncertainty_score":0.0922507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094207412657491,"score_gpt":0.2968891777382872,"score_spread":0.2859471036117123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}