{"id":"W4407946809","doi":"10.1016/s0140-6736(25)00333-2","title":"Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Intracerebral and Subarachnoid Hemorrhage Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; Population Health Research Institute","funders":"Robert Koch Institut; Universitätsklinikum Heidelberg; Servier; Deutsche Krebshilfe; Deutsche Herzstiftung; Daiichi-Sankyo; Bundesministerium für Bildung und Forschung; Gemeinsame Bundesausschuss; Deutsche Forschungsgemeinschaft; Alexion Pharmaceuticals; Horizon 2020 Framework Programme; Universitätsklinikum Essen; Horizon 2020; Biogen; Daiichi Sankyo Europe; University of Thessaly; European Commission; Sanofi; Imperial College London; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; AstraZeneca; Pfizer; Amgen","keywords":"Atrial fibrillation; Medicine; Stroke (engine); Randomized controlled trial; Rivaroxaban; Open label; Warfarin; Intracerebral hemorrhage; Internal medicine; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001838714,0.0001710498,0.0009617005,0.0001288745,0.0001233704,0.00004733888,0.0003334861,0.0001035253,0.00004958451],"category_scores_gemma":[0.001373576,0.00009419402,0.0001276746,0.0004032096,0.000162799,0.0001607011,0.00009127855,0.0002104752,0.00000244996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005254246,"about_ca_system_score_gemma":0.0002414803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006596039,"about_ca_topic_score_gemma":0.0006332156,"domain_scores_codex":[0.9981142,0.0003452279,0.0005831127,0.0002471542,0.0003707508,0.0003395618],"domain_scores_gemma":[0.9974919,0.001462959,0.0002790781,0.0004802354,0.0002464291,0.00003938164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9394277,0.0004082373,0.006842694,0.0004775134,0.0003907483,0.00000476314,0.0002494651,0.0005853368,0.005427614,0.0002943588,0.0002547964,0.04563682],"study_design_scores_gemma":[0.6829487,0.002325956,0.00346601,0.0002989405,0.0005660967,0.000002709972,0.000142293,0.3005867,0.009370499,0.00006609938,0.0001092404,0.0001167799],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892291,0.0003422874,0.001557363,0.0008950126,0.0004876863,0.006668584,0.00009387022,0.00001986543,0.0007062032],"genre_scores_gemma":[0.995777,0.0001134647,0.002606766,0.0000176028,0.0006445854,0.00004911983,0.00007829348,0.00001601752,0.0006972186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3000013,"threshold_uncertainty_score":0.3841121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08030163396156993,"score_gpt":0.3906306190608901,"score_spread":0.3103289850993202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}