{"id":"W4407946809","doi":"10.1016/s0140-6736(25)00333-2","title":"Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Intracerebral and Subarachnoid Hemorrhage Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; Population Health Research Institute","funders":"Robert Koch Institut; Universitätsklinikum Heidelberg; Servier; Deutsche Krebshilfe; Deutsche Herzstiftung; Daiichi-Sankyo; Bundesministerium für Bildung und Forschung; Gemeinsame Bundesausschuss; Deutsche Forschungsgemeinschaft; Alexion Pharmaceuticals; Horizon 2020 Framework Programme; Universitätsklinikum Essen; Horizon 2020; Biogen; Daiichi Sankyo Europe; University of Thessaly; European Commission; Sanofi; Imperial College London; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; AstraZeneca; Pfizer; Amgen","keywords":"Atrial fibrillation; Medicine; Stroke (engine); Randomized controlled trial; Rivaroxaban; Open label; Warfarin; Intracerebral hemorrhage; Internal medicine; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003251443,0.001703496,0.002562186,0.0003874041,0.0005827489,0.001437182,0.0009545657,0.002280201,0.009231277],"category_scores_gemma":[0.00386528,0.0004748154,0.002842645,0.0004765507,0.001119123,0.001126024,0.0005000088,0.002400393,0.0009743497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007240591,"about_ca_system_score_gemma":0.00158765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008434633,"about_ca_topic_score_gemma":0.002159876,"domain_scores_codex":[0.9989055,0.0005879269,0.00009860539,0.0001672086,0.000105441,0.0001353152],"domain_scores_gemma":[0.9982376,0.000536262,0.0004809747,0.0001264283,0.0001379999,0.0004806735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9855788,0.002327934,0.0005665423,0.001319906,0.001227167,0.0000626522,0.00006648634,0.0001515583,0.001005486,0.0001232235,0.001059459,0.006510845],"study_design_scores_gemma":[0.9783924,0.01939862,0.0009653041,0.00004756694,0.0004688124,0.00003862428,0.00001127352,0.0001236758,0.00008089426,0.0001173476,0.0003466816,0.000008737122],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712121,0.009732026,0.0007150318,0.00175239,0.0009760431,0.009174263,0.002538875,0.0001242922,0.003774952],"genre_scores_gemma":[0.9685291,0.004800681,0.002521093,0.002933891,0.001261561,0.01301895,0.003066454,0.00002996596,0.00383817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009231277,"threshold_uncertainty_score":0.03088164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08030163396156993,"score_gpt":0.3906306190608901,"score_spread":0.3103289850993202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}