{"id":"W4407953821","doi":"10.1182/blood.2024027020","title":"NOTCH1 dimeric signaling is essential for T-cell leukemogenesis and leukemia maintenance","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"","keywords":"Biology; Notch signaling pathway; Progenitor cell; Haematopoiesis; Cancer research; Leukemia; Cell biology; Signal transduction; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211037,0.0002384064,0.0001745641,0.0001432903,0.0001871616,0.0004131251,0.0001927456,0.0001917707,0.001437448],"category_scores_gemma":[0.000118213,0.0001043537,0.0001322968,0.0001365416,0.0001544656,0.0001546638,0.0002411505,0.000299475,0.000446112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002443414,"about_ca_system_score_gemma":0.0002264406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002127053,"about_ca_topic_score_gemma":0.0002242433,"domain_scores_codex":[0.9998509,0.00003400796,0.00001537623,0.00003767857,0.00003272482,0.00002924286],"domain_scores_gemma":[0.9998845,0.00001033901,0.00004418806,0.00001309858,0.0000113441,0.00003647938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007270824,0.00001181448,0.0003723378,0.00001920981,0.000002933458,0.00003263507,0.000006565095,0.00004810532,0.9984019,0.0001053145,0.00002767767,0.0008986905],"study_design_scores_gemma":[0.00001469202,0.0001483714,0.008273184,0.00000640686,0.00001812538,0.0005418502,0.00004212878,0.001123592,0.9865813,0.000132936,0.003113666,0.000003737809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934441,0.001372513,0.003329171,0.00008766518,0.00001591735,0.00002336767,0.0004630004,0.0001109394,0.00115342],"genre_scores_gemma":[0.9977063,0.0003100224,0.0008275148,0.0000251679,0.000004634968,0.000009294426,0.0003539946,0.00001158039,0.0007514397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001437448,"threshold_uncertainty_score":0.004808784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008653717296840897,"score_gpt":0.2670722429610097,"score_spread":0.2584185256641688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}