{"id":"W4407959307","doi":"10.1016/j.ijpddr.2025.100587","title":"Increased activity of CF3-derivatized levamisole at the ACC-2 receptor from the parasitic nematode Haemonchus contortus","year":2025,"lang":"en","type":"article","venue":"International Journal for Parasitology Drugs and Drug Resistance","topic":"Helminth infection and control","field":"Veterinary","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada; Zoetis","keywords":"Haemonchus contortus; Levamisole; Nematode; Pyrantel; Biology; Anthelmintic; Pharmacology; Helminths; Veterinary medicine; Microbiology; Traditional medicine; Immunology; Medicine; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007733349,0.0002436365,0.0001586262,0.0000813284,0.00006021205,0.00008904364,0.0001727866,0.0002452682,0.001152317],"category_scores_gemma":[0.0001193371,0.00006286276,0.0002160372,0.00006632317,0.00009621557,0.0001248479,0.00008987273,0.0002785685,0.0001851057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001016621,"about_ca_system_score_gemma":0.00009797516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004748765,"about_ca_topic_score_gemma":0.001156738,"domain_scores_codex":[0.9999547,0.00001029108,0.000004013627,0.000006293802,0.00001124319,0.00001343895],"domain_scores_gemma":[0.9999585,0.000008249027,0.00001227996,0.000004498613,0.000008813327,0.000007585132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001101521,0.00001761418,0.00007956883,0.00004692506,0.000008239019,0.00008208538,0.000008517359,0.00006624372,0.9984949,0.0000172398,0.00001795849,0.001050629],"study_design_scores_gemma":[0.00002607562,0.001752264,0.002349028,0.000007304357,0.00002805392,0.0003853384,0.00002101727,0.0003598948,0.9938168,0.00001161784,0.00123642,0.0000061863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967368,0.001247428,0.001020184,0.00005365025,0.00002042246,0.00001992686,0.0001460209,0.00002082959,0.0007347236],"genre_scores_gemma":[0.9963126,0.0009723668,0.001275528,0.00005916741,0.000008038027,0.00001122757,0.0003180049,0.000004214769,0.001038932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152317,"threshold_uncertainty_score":0.003854871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02002297221307894,"score_gpt":0.3583676902760668,"score_spread":0.3383447180629879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}