{"id":"W4407959307","doi":"10.1016/j.ijpddr.2025.100587","title":"Increased activity of CF3-derivatized levamisole at the ACC-2 receptor from the parasitic nematode Haemonchus contortus","year":2025,"lang":"en","type":"article","venue":"International Journal for Parasitology Drugs and Drug Resistance","topic":"Helminth infection and control","field":"Veterinary","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada; Zoetis","keywords":"Haemonchus contortus; Levamisole; Nematode; Pyrantel; Biology; Anthelmintic; Pharmacology; Helminths; Veterinary medicine; Microbiology; Traditional medicine; Immunology; Medicine; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005490562,0.0001873173,0.0003558566,0.00006610576,0.0005256786,0.0000987292,0.0004970492,0.0000988915,0.0001859242],"category_scores_gemma":[0.0006547304,0.0001186503,0.000208785,0.00008298852,0.0002984899,0.0001299269,0.00007099881,0.0002877167,0.00001131396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000135028,"about_ca_system_score_gemma":0.0001375381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000450801,"about_ca_topic_score_gemma":0.00105501,"domain_scores_codex":[0.9983802,0.000368484,0.0004903848,0.0002567023,0.0002699386,0.0002343133],"domain_scores_gemma":[0.9956729,0.003224301,0.0004291291,0.0002605526,0.000341583,0.00007156921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.06767541,0.001225993,0.2364815,0.0001686157,0.006664732,0.0002306127,0.006247714,0.00005619986,0.2072229,0.04010478,0.3822055,0.05171609],"study_design_scores_gemma":[0.0180533,0.0002513223,0.3830025,0.0006777609,0.0004762416,0.0004077969,0.002003394,0.00139624,0.0362609,0.02013205,0.5365925,0.0007459576],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714396,0.001460389,0.002274022,0.02003547,0.001902474,0.0003691895,0.000168811,0.00002389804,0.002326156],"genre_scores_gemma":[0.9944132,0.0001699535,0.000100852,0.00146304,0.0002645898,0.00008462132,0.00001714136,0.00001209153,0.003474489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.170962,"threshold_uncertainty_score":0.483842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02002297221307894,"score_gpt":0.3583676902760668,"score_spread":0.3383447180629879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}