{"id":"W4407976024","doi":"10.1161/jaha.124.036336","title":"Plasma Proteomic Assessment of Calcific Aortic Valve Disease in Older Adults","year":2025,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Mendelian randomization; Medicine; Cohort; Internal medicine; Aortic valve; Biomarker; Aortic valve stenosis; Oncology; Bioinformatics; Cardiology; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005979557,0.0003423447,0.0002945261,0.0006460515,0.0002741764,0.0004743144,0.0001747435,0.0004117307,0.0007071462],"category_scores_gemma":[0.001050946,0.000129788,0.0002270455,0.0004839192,0.0001381531,0.0001500978,0.0003221495,0.0002327993,0.0001580722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001251474,"about_ca_system_score_gemma":0.0001064517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007263394,"about_ca_topic_score_gemma":0.0008313824,"domain_scores_codex":[0.999768,0.0000495757,0.00002745518,0.0000861157,0.00004648766,0.00002247051],"domain_scores_gemma":[0.9995852,0.0000802849,0.0001570486,0.00002884405,0.00008972124,0.00005893903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001161016,0.000104252,0.9482266,0.000142008,0.000197741,0.0002594836,0.0002339118,0.0001722805,0.038148,0.00004852702,0.0003930661,0.01091319],"study_design_scores_gemma":[0.00002447048,0.0004120197,0.9946424,0.00001301621,0.00009718172,0.0007069164,0.0001324175,0.0003758103,0.003047048,0.00007117925,0.0004706616,0.000006960146],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977171,0.0008506984,0.000445191,0.0000422709,0.00001358838,0.00001824677,0.0005577705,0.0000164273,0.0003387101],"genre_scores_gemma":[0.9976838,0.0003057848,0.001178452,0.00007602183,0.00002006084,0.00002362853,0.0003936342,0.000002939228,0.0003156567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007263394,"threshold_uncertainty_score":0.003162324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005809487683360605,"score_gpt":0.3411083269215013,"score_spread":0.3352988392381407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}