{"id":"W4407976914","doi":"10.1016/j.jtct.2025.01.098","title":"A CD33-Deleted Allograft (Trem-cel) Enables Post-Hematopoietic Cell Transplant (HCT) Maintenance Dosing of Gemtuzumab Ozogamicin (GO) with Therapeutic Levels of Drug Exposure and Low Hematologic and Hepatic Toxicity in Patients with High-Risk Acute Myeloid Leukemia (AML)","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Gemtuzumab ozogamicin; Dosing; Calicheamicin; Toxicity; Medicine; Therapeutic index; Pharmacology; Hematopoietic cell; Hematopoietic stem cell transplantation; Therapeutic drug monitoring; Drug; CD33; Haematopoiesis; Internal medicine; Transplantation; Stem cell; Myeloid leukemia; CD34; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003050788,0.0003768551,0.0008045963,0.0003475522,0.0001015711,0.0000238209,0.0001208843,0.0001628529,0.00001604668],"category_scores_gemma":[0.000003744276,0.000258489,0.00005606935,0.0004201158,0.000395435,0.0001321516,0.00001072278,0.0003589724,2.895566e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001007224,"about_ca_system_score_gemma":0.0002557992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004032182,"about_ca_topic_score_gemma":0.0001885032,"domain_scores_codex":[0.9979347,0.0002308974,0.000562141,0.0004960758,0.0003893092,0.0003868604],"domain_scores_gemma":[0.9989813,0.0002180085,0.000230109,0.0002767229,0.0001850217,0.0001088158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01790841,0.0006729627,0.4234758,0.00446336,0.0007309997,0.0002328237,0.01382762,0.00009033846,0.5329289,0.0002184841,0.000003098398,0.005447231],"study_design_scores_gemma":[0.03376716,0.002530478,0.3977195,0.002015254,0.0006818784,0.00009666127,0.001043805,0.0008418941,0.5607144,0.0001779679,0.000004964581,0.0004060814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932076,0.001959464,0.003177922,0.0001608491,0.00001521404,0.001263046,0.0001428047,0.00003283164,0.00004028646],"genre_scores_gemma":[0.9913332,0.007394335,0.000799077,0.0001940701,0.000004077987,0.00003113667,0.0001227045,0.00003672769,0.00008464758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02778547,"threshold_uncertainty_score":0.9999867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005868945256474293,"score_gpt":0.2137211798373854,"score_spread":0.2078522345809111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}