{"id":"W4407976914","doi":"10.1016/j.jtct.2025.01.098","title":"A CD33-Deleted Allograft (Trem-cel) Enables Post-Hematopoietic Cell Transplant (HCT) Maintenance Dosing of Gemtuzumab Ozogamicin (GO) with Therapeutic Levels of Drug Exposure and Low Hematologic and Hepatic Toxicity in Patients with High-Risk Acute Myeloid Leukemia (AML)","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Gemtuzumab ozogamicin; Dosing; Calicheamicin; Toxicity; Medicine; Therapeutic index; Pharmacology; Hematopoietic cell; Hematopoietic stem cell transplantation; Therapeutic drug monitoring; Drug; CD33; Haematopoiesis; Internal medicine; Transplantation; Stem cell; Myeloid leukemia; CD34; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002099233,0.0002150612,0.0001809654,0.0001356969,0.0001215848,0.0002770886,0.0001999221,0.0002183617,0.001591936],"category_scores_gemma":[0.0001234917,0.00009231534,0.0001514481,0.00009774792,0.0001668786,0.0002517692,0.0001935041,0.0007953255,0.0004155439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001514044,"about_ca_system_score_gemma":0.0002545852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001788251,"about_ca_topic_score_gemma":0.0003122938,"domain_scores_codex":[0.9999175,0.00001567809,0.000005691901,0.00001576205,0.00001659899,0.00002872123],"domain_scores_gemma":[0.9999251,0.000007262931,0.00002238333,0.00001250771,0.000004404951,0.00002831651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002869055,0.001139814,0.002709238,0.00005808406,0.00003759005,0.0003351933,0.00005237958,0.0005179193,0.9635938,0.001182783,0.000720511,0.02678368],"study_design_scores_gemma":[0.002051267,0.02233904,0.03434653,0.00003040659,0.000345335,0.005651725,0.0001304682,0.007762779,0.9053518,0.0005484016,0.02141281,0.00002940934],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973904,0.0001987844,0.001397971,0.00007983026,0.0000207003,0.00003999414,0.000105031,0.00009188959,0.000675365],"genre_scores_gemma":[0.9977254,0.0001052862,0.001319716,0.00005646284,0.000007157103,0.00002081607,0.0002253707,0.00001172145,0.0005279618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591936,"threshold_uncertainty_score":0.005325615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005868945256474293,"score_gpt":0.2137211798373854,"score_spread":0.2078522345809111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}