{"id":"W4407978630","doi":"10.1038/s41551-025-01360-5","title":"Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades","year":2025,"lang":"en","type":"article","venue":"Nature Biomedical Engineering","topic":"Tardigrade Biology and Ecology","field":"Agricultural and Biological Sciences","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; Prostate Cancer Foundation; U.S. Department of Defense","keywords":"Messenger RNA; Suppressor; Cell biology; Molecular biology; Chemistry; Biophysics; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003177693,0.0001293079,0.0002688035,0.00006666526,0.00007474024,0.000009392367,0.000182896,0.0005536405,0.00003017975],"category_scores_gemma":[0.0004106051,0.00006429499,0.00006139569,0.0006065324,0.00006870897,0.00006616064,0.00004379576,0.0003701292,0.000001333187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006084918,"about_ca_system_score_gemma":0.00001646044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001049373,"about_ca_topic_score_gemma":0.0001272628,"domain_scores_codex":[0.9989678,0.00003814566,0.0002939677,0.0002626859,0.0001013492,0.0003360912],"domain_scores_gemma":[0.9995536,0.0002169373,0.00005775056,0.00005198995,0.00004524019,0.00007451769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00014228,0.00007565704,0.0004502722,0.0001163389,0.0000207779,0.000003613963,0.00002696808,0.00007072034,0.9881818,0.0005320364,0.00009502625,0.01028445],"study_design_scores_gemma":[0.003664624,0.003338178,0.2051158,0.0007360837,0.00006717576,0.0000302765,0.0002173673,0.02371199,0.598165,0.002074281,0.1619803,0.0008988906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948633,0.0008753524,0.0006473711,0.002312215,0.0004964566,0.0006904899,0.0000214833,0.00007155655,0.00002180034],"genre_scores_gemma":[0.9986444,0.000007491841,0.000881739,0.00009348973,0.0001673502,0.000140258,0.0000292774,0.000001338678,0.0000347314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3900168,"threshold_uncertainty_score":0.4270183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006176695037118996,"score_gpt":0.2327577669800602,"score_spread":0.2265810719429412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}