{"id":"W4407979287","doi":"10.3390/molecules30051062","title":"The Development and Validation of a Simple HPLC-UV Method for the Determination of Vancomycin Concentration in Human Plasma and Application in Critically Ill Patients","year":2025,"lang":"en","type":"article","venue":"Molecules","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta; University Hospital Foundation","keywords":"Critically ill; Vancomycin; High-performance liquid chromatography; Human plasma; Chromatography; Simple (philosophy); Plasma concentration; Chemistry; Intensive care medicine; Medicine; Pharmacology; Staphylococcus aureus; Biology; Bacteria; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00313441,0.0008926908,0.0007012209,0.001046678,0.0006520265,0.0007186134,0.0006928582,0.00180203,0.0008583267],"category_scores_gemma":[0.003618206,0.000488703,0.0006123165,0.0006194488,0.0007626038,0.0004700793,0.0006199456,0.001094899,0.0006130905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004075482,"about_ca_system_score_gemma":0.002079731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009716252,"about_ca_topic_score_gemma":0.002232011,"domain_scores_codex":[0.9948319,0.001990905,0.0003013379,0.0007992059,0.00194,0.0001366497],"domain_scores_gemma":[0.9985499,0.0004387577,0.0002959646,0.0001219625,0.0004811972,0.0001123666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004312219,0.000349714,0.004939306,0.0005722495,0.00009229008,0.0002969924,0.0001919671,0.0005753994,0.9339188,0.0004602609,0.0006392103,0.05753268],"study_design_scores_gemma":[0.0001863367,0.005020943,0.02496967,0.0002114054,0.0003030782,0.006180296,0.0002358787,0.01171958,0.9300088,0.0008009057,0.02016874,0.0001942753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2731506,0.01706333,0.6988994,0.001369376,0.0007903726,0.002416313,0.001088759,0.001473178,0.003748574],"genre_scores_gemma":[0.5121317,0.005474913,0.4752921,0.001363746,0.0002572448,0.001494003,0.0006124896,0.0001096404,0.003264149],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00313441,"threshold_uncertainty_score":0.01657659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01254775477380882,"score_gpt":0.3380889254865819,"score_spread":0.3255411707127731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}