{"id":"W4407989574","doi":"10.1016/j.neuropharm.2025.110386","title":"β-2 agonist and antagonist adrenoceptors induce neuroprotection in a progressive model of parkinsonism","year":2025,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Neuroprotection; Agonist; Parkinsonism; Antagonist; Neuroscience; Pharmacology; Medicine; Receptor; Internal medicine; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002731052,0.0006307692,0.000678056,0.0005939977,0.0003364104,0.0003493374,0.0004243333,0.0006613832,0.002030188],"category_scores_gemma":[0.0001865587,0.0002626237,0.0004346359,0.0003138252,0.0004592656,0.0004931244,0.0002044278,0.001531619,0.0003585875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000339498,"about_ca_system_score_gemma":0.0005253474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002122256,"about_ca_topic_score_gemma":0.004406327,"domain_scores_codex":[0.999831,0.00002658024,0.00001447727,0.00002642298,0.00002993711,0.00007170098],"domain_scores_gemma":[0.9998172,0.00003020593,0.00004169297,0.00001921687,0.00001931554,0.00007239787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008114194,0.001135981,0.0002866806,0.0001018947,0.00004626689,0.0003592482,0.0001015919,0.0001762959,0.9850394,0.0002334379,0.00024231,0.004162744],"study_design_scores_gemma":[0.001288398,0.02641991,0.009095756,0.00004703367,0.0001825018,0.0007750564,0.0002438131,0.001851357,0.9577757,0.0002666668,0.002025706,0.00002826703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966109,0.001093843,0.0003857986,0.0001185784,0.00006151129,0.00004360044,0.0002438712,0.00004667396,0.001395111],"genre_scores_gemma":[0.9939103,0.001261059,0.0005404262,0.00007174449,0.00003025507,0.00005814114,0.0003577433,0.00001130539,0.003759044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002122256,"threshold_uncertainty_score":0.006791651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829259882842851,"score_gpt":0.305826857242661,"score_spread":0.2875342584142325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}