{"id":"W4408006876","doi":"10.1101/2025.02.26.25322913","title":"Early White Matter Microstructure Alterations in Infants with Down Syndrome","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; University of Alberta","funders":"National Institutes of Health","keywords":"White matter; Microstructure; White (mutation); Medicine; Materials science; Magnetic resonance imaging; Metallurgy; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003157847,0.0003330796,0.0002144528,0.0006915627,0.000208445,0.0002790901,0.0001440346,0.0002442349,0.000798983],"category_scores_gemma":[0.00114321,0.000160357,0.0001475191,0.0002597148,0.0002240234,0.0001809008,0.0002568854,0.0001873605,0.00007853594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003071539,"about_ca_system_score_gemma":0.0001822441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004235477,"about_ca_topic_score_gemma":0.005702535,"domain_scores_codex":[0.9998227,0.00002970944,0.00002362512,0.00004887135,0.00004495967,0.00003024085],"domain_scores_gemma":[0.9995689,0.00006800675,0.0002259348,0.00001944298,0.0000674056,0.00005028937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001906853,0.00002626384,0.9853324,0.00002594729,0.00002461783,0.001582117,0.0003351246,0.00004167904,0.00859745,0.00002263484,0.00006658678,0.003754496],"study_design_scores_gemma":[0.000001443127,0.00006163575,0.9979497,0.000006558605,0.000009778604,0.001214717,0.00009225476,0.00004584654,0.0005659789,0.000006993894,0.00004394901,0.000001295197],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999738,0.00008724784,0.00005041838,0.000007284017,7.757275e-7,0.000002582978,0.00005223343,0.000002071821,0.00005933144],"genre_scores_gemma":[0.9994648,0.0001333832,0.0001704704,0.000009417721,0.000002025886,0.000006505113,0.0001048773,0.000001258136,0.0001072621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004235477,"threshold_uncertainty_score":0.008421659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966907564007711,"score_gpt":0.3030736510193452,"score_spread":0.2834045753792681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}