{"id":"W4408007933","doi":"10.1177/02698811251319456","title":"Acute subanesthetic ketamine-induced effects on the mismatch negativity and their relationship to early and sustained treatment response in major depressive disorder","year":2025,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre; University of Ottawa","funders":"Canadian Institutes of Health Research; Mental Health Research Canada","keywords":"Mismatch negativity; Ketamine; Anesthesia; Psychology; NMDA receptor; Major depressive disorder; Audiology; Midazolam; Electroencephalography; Medicine; Internal medicine; Neuroscience; Cognition; Sedation; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001776848,0.0001847981,0.0003275918,0.00006180235,0.00005233909,0.0001134792,0.0001246788,0.000118681,0.001021981],"category_scores_gemma":[0.0004080328,0.00010571,0.000119398,0.00006052781,0.000150174,0.0001076838,0.00008042743,0.00034897,0.0001390379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001365494,"about_ca_system_score_gemma":0.0001184656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001938526,"about_ca_topic_score_gemma":0.0006011666,"domain_scores_codex":[0.999928,0.00002266094,0.000009917986,0.00001142286,0.00001442006,0.00001362096],"domain_scores_gemma":[0.9998435,0.00002854155,0.0000642927,0.00001410973,0.00001260339,0.00003695418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.08962807,0.004882139,0.01459044,0.0003010463,0.0002029239,0.0001874432,0.0001508976,0.0003002989,0.8368465,0.00007431504,0.0002835373,0.05255239],"study_design_scores_gemma":[0.006475699,0.2557271,0.5148216,0.00004505637,0.0003587385,0.001223902,0.0001724934,0.001599486,0.217964,0.0001466572,0.001438042,0.00002714495],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995161,0.0001938403,0.00008977076,0.000009343396,0.000005335743,0.00002630355,0.00005551632,0.000004356501,0.00009934339],"genre_scores_gemma":[0.9992241,0.0002085889,0.0001974339,0.00001971055,0.000006245542,0.00005023273,0.00009623574,0.000001794289,0.0001958245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021981,"threshold_uncertainty_score":0.003418863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335638995730765,"score_gpt":0.3306193201732276,"score_spread":0.3172629302159199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}