{"id":"W4408014611","doi":"10.1016/j.ctrv.2025.102909","title":"First versus second-generation molecular profiling tests: How both can guide decision-making in early-stage hormone-receptor positive breast cancers?","year":2025,"lang":"en","type":"review","venue":"Cancer Treatment Reviews","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Génome Québec","keywords":"Medicine; Oncology; Hormone receptor; Profiling (computer programming); Stage (stratigraphy); Internal medicine; Breast cancer; Gynecology; Cancer research; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00219618,0.0008211358,0.00251996,0.001341972,0.0001950187,0.001827531,0.001361167,0.001652375,0.004675727],"category_scores_gemma":[0.003833569,0.0002651729,0.001116551,0.001447542,0.0005954371,0.001655829,0.0005574113,0.003082677,0.00190803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008662583,"about_ca_system_score_gemma":0.001703348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002565979,"about_ca_topic_score_gemma":0.005601478,"domain_scores_codex":[0.999456,0.0001966191,0.00005319568,0.00009003319,0.0001580393,0.00004626109],"domain_scores_gemma":[0.9978995,0.001434058,0.0001629337,0.00003993907,0.0003792259,0.00008427488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002073474,0.00005212343,0.000404208,0.007962691,0.0002497979,0.00008812601,0.00002730904,0.0002788622,0.0004969506,0.003717639,0.03908123,0.9474337],"study_design_scores_gemma":[0.0001577258,0.0002829566,0.002279478,0.01428078,0.0008672721,0.001169181,0.0001204304,0.0003100432,0.0004848913,0.007835166,0.9721459,0.00006617532],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005933858,0.9979436,0.0001704739,0.001102446,0.0002724849,0.000003158825,0.00003235053,0.000005760671,0.0004104058],"genre_scores_gemma":[0.000997966,0.9965648,0.0005056158,0.001060338,0.0004367648,0.000007828681,0.00005106879,0.000002829361,0.000372836],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004675727,"threshold_uncertainty_score":0.01564181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03352632896965108,"score_gpt":0.3504229687075084,"score_spread":0.3168966397378574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}