{"id":"W4408029160","doi":"10.1681/asn.0000000614","title":"Rac1 Suppression by the Focal Adhesion Protein GIT ArfGAP2 and Podocyte Protection","year":2025,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Osaka Kidney Foundation; Kidney Foundation of Canada; Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care; Japan Foundation for Applied Enzymology","keywords":"Podocyte; Gene knockdown; Focal adhesion; RAC1; Biology; Cell biology; PTK2; Adapter molecule crk; Protocadherin; Cell adhesion; Tyrosine; Actin cytoskeleton; Kidney; Cytoskeleton; Signal transduction; Cadherin; Phosphorylation; Biochemistry; Signal transducing adaptor protein; Cell; Protein kinase A; Proteinuria; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137696,0.0004560735,0.0002598909,0.0004146162,0.0002510702,0.0003482792,0.0002362509,0.0004239367,0.002315507],"category_scores_gemma":[0.00009323454,0.0001714008,0.0005253264,0.0002084392,0.0002289455,0.0002376104,0.0002780646,0.0008417263,0.0004249359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003048353,"about_ca_system_score_gemma":0.0002763212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005741214,"about_ca_topic_score_gemma":0.0007754205,"domain_scores_codex":[0.9998075,0.0000254739,0.00001611465,0.00004169964,0.00005282929,0.00005636583],"domain_scores_gemma":[0.9999254,0.000005103707,0.00001903603,0.00001062195,0.00001098525,0.00002881889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002509544,0.00004128322,0.0001338002,0.00008507967,0.00001349609,0.00008062598,0.00001815621,0.00006335526,0.9967201,0.0003643399,0.0002681258,0.001960598],"study_design_scores_gemma":[0.00005009381,0.0003652121,0.005227721,0.00001293936,0.00003818391,0.0006470298,0.00003868352,0.00151252,0.9814304,0.0001418133,0.01052697,0.000008561112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801589,0.005381178,0.005338543,0.0007313458,0.0001592555,0.00008029525,0.0009556759,0.0004266749,0.00676808],"genre_scores_gemma":[0.9882434,0.001779016,0.002210741,0.000135133,0.00002972064,0.0001076137,0.000909623,0.00004386399,0.006540871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002315507,"threshold_uncertainty_score":0.00774622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028275934923585,"score_gpt":0.2713837494111624,"score_spread":0.2611009900619266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}