{"id":"W4408030311","doi":"10.1021/acsomega.4c10493","title":"SI/II Pocket of Ras: An Opportunity for a Once “Undruggable” Target","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec; Université Laval; PROTEO; Institut National de la Recherche Scientifique","funders":"Mitacs; Québec Consortium for Drug Discovery; Institut national de la recherche scientifique","keywords":"Chemistry; Computational biology; Computer science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002657279,0.0000996733,0.0001379996,0.00005218096,0.0001120428,0.00001016085,0.0001534975,0.0001115943,0.00001694501],"category_scores_gemma":[0.0001932395,0.0001010233,0.00006944702,0.0001033866,0.00004892587,0.000006071306,0.00008726674,0.00004405592,5.8643e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009184192,"about_ca_system_score_gemma":0.0002010431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001378041,"about_ca_topic_score_gemma":0.000007549767,"domain_scores_codex":[0.9993095,0.00004345031,0.0001947548,0.0002204288,0.00007145796,0.0001604247],"domain_scores_gemma":[0.9993924,0.0000139184,0.0000816642,0.000308404,0.000128508,0.00007509641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001805338,0.0001048095,0.0001952321,0.00008313423,0.00005266023,9.85468e-7,0.00003813992,0.0001202264,0.9867048,0.002068127,0.004783301,0.005668044],"study_design_scores_gemma":[0.0006385966,0.0002130383,0.0002444371,0.00003099654,0.00001436668,0.00000142124,0.00007394971,0.0002507356,0.8523094,0.003291182,0.1428049,0.0001270302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764726,0.001379833,0.01809285,0.00035285,0.0001126776,0.0004113375,0.0000901179,0.00002007607,0.003067656],"genre_scores_gemma":[0.9924054,0.0000276199,0.00416892,0.0008443625,0.00007648292,0.00004433062,0.0002948761,0.00001062808,0.00212739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1380216,"threshold_uncertainty_score":0.411961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813368528395124,"score_gpt":0.2885350716207983,"score_spread":0.2704013863368471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}