{"id":"W4408030311","doi":"10.1021/acsomega.4c10493","title":"SI/II Pocket of Ras: An Opportunity for a Once “Undruggable” Target","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec; Université Laval; PROTEO; Institut National de la Recherche Scientifique","funders":"Mitacs; Québec Consortium for Drug Discovery; Institut national de la recherche scientifique","keywords":"Chemistry; Computational biology; Computer science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558404,0.0002828683,0.0003321173,0.00008385214,0.0002257398,0.0006830886,0.0004126978,0.0004057283,0.003736735],"category_scores_gemma":[0.0002338772,0.0001669324,0.0002414698,0.00009273436,0.0003300696,0.0008012811,0.0004314744,0.0009599115,0.0006333578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002727276,"about_ca_system_score_gemma":0.0002849276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005416173,"about_ca_topic_score_gemma":0.0007344882,"domain_scores_codex":[0.9999365,0.00001120618,0.000002170153,0.00001166931,0.00002552836,0.00001303061],"domain_scores_gemma":[0.9999402,0.00001724537,0.000007584479,0.00001208446,0.000008213551,0.00001464074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001058072,0.0001287902,0.0009259828,0.0003430151,0.00004027848,0.0007152684,0.0002923557,0.01033968,0.9111345,0.02463292,0.007296903,0.04309224],"study_design_scores_gemma":[0.0003490568,0.001983802,0.003318797,0.0001740732,0.0001056632,0.002712029,0.0006355522,0.1026828,0.654906,0.02601519,0.2069724,0.0001446459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8552403,0.01203806,0.08842059,0.008819599,0.0008159311,0.0001012188,0.000898825,0.003035062,0.03063029],"genre_scores_gemma":[0.9536739,0.005692067,0.03125875,0.0007711887,0.00008114018,0.00004863485,0.0007752858,0.0002537679,0.007445204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003736735,"threshold_uncertainty_score":0.01250064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813368528395124,"score_gpt":0.2885350716207983,"score_spread":0.2704013863368471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}