{"id":"W4408037862","doi":"10.1101/2025.02.23.639782","title":"RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; McGill University","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Dual (grammatical number); Vulnerability (computing); Cancer research; Melanoma; Discovery and development of mTOR inhibitors; Medicine; Chemistry; Apoptosis; Art; Computer science; Literature; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008734068,0.0002980403,0.0002456003,0.0002495402,0.0001677276,0.0002655182,0.0001111457,0.0002624222,0.001689021],"category_scores_gemma":[0.00005159673,0.0001050893,0.0002311381,0.0001242091,0.0001714023,0.0001138203,0.0001729239,0.0003923719,0.0003779493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002460435,"about_ca_system_score_gemma":0.0001347318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005073993,"about_ca_topic_score_gemma":0.0007399812,"domain_scores_codex":[0.9999448,0.000008530507,0.000003766643,0.00001336627,0.00001523278,0.00001418303],"domain_scores_gemma":[0.99998,0.000002414219,0.000005885003,0.00000259751,0.000002214263,0.000006938607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001245506,0.00001582527,0.0002229479,0.00002655708,0.000006756487,0.0001206461,0.000005806475,0.00004616248,0.9978783,0.0001134138,0.0001070502,0.001331909],"study_design_scores_gemma":[0.00002024425,0.0001954987,0.007684976,0.000006198561,0.00002748941,0.0011184,0.00002639721,0.001754934,0.9854926,0.0001388628,0.003530019,0.000004406039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885517,0.003595645,0.003380061,0.0004464443,0.00006826475,0.00002489608,0.0005427654,0.0001940003,0.00319622],"genre_scores_gemma":[0.9932406,0.00119236,0.001531049,0.0000768246,0.00001289623,0.00002166101,0.0002641625,0.00002704735,0.00363332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001689021,"threshold_uncertainty_score":0.005650342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403129902881098,"score_gpt":0.2561929860100587,"score_spread":0.2421616869812478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}