{"id":"W4408040085","doi":"10.1016/j.yrtph.2025.105798","title":"Subchronic safety assessment of CIGB-500 in beagle dog after repeated daily dose administration over 28 days","year":2025,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"International Civil Aviation Organization","funders":"","keywords":"Beagle; Pharmacology; Medicine; Toxicology; Chemistry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004012882,0.0005237153,0.0005488587,0.0005209392,0.000425664,0.0003977841,0.0003660368,0.0006858903,0.001594226],"category_scores_gemma":[0.0003653578,0.0002650177,0.0005529613,0.0003532811,0.0005618248,0.0003387859,0.0001849009,0.0007981224,0.0004795024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995401,"about_ca_system_score_gemma":0.0006540608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002297499,"about_ca_topic_score_gemma":0.004752423,"domain_scores_codex":[0.999687,0.00005677452,0.00001824058,0.00009699891,0.0000890845,0.0000519596],"domain_scores_gemma":[0.9996358,0.00005891256,0.00008464466,0.00006318683,0.00009678642,0.00006070213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007746145,0.002821313,0.00633284,0.0001390473,0.00009912313,0.0004133821,0.0004024037,0.0007157071,0.9603059,0.0002124789,0.000556173,0.02025559],"study_design_scores_gemma":[0.0003059007,0.09094761,0.03228002,0.00004934881,0.0004814576,0.000815206,0.0007965888,0.003285606,0.8638319,0.0002535009,0.006890175,0.00006271296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950964,0.001386704,0.001772977,0.00009585456,0.00005944337,0.0001276051,0.0002618511,0.00005880768,0.001140412],"genre_scores_gemma":[0.9891432,0.001566915,0.001917499,0.0001346653,0.00003982361,0.0001625678,0.0005663437,0.00002929606,0.006439519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002297499,"threshold_uncertainty_score":0.005333185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01009780473243522,"score_gpt":0.3287431999106641,"score_spread":0.3186453951782289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}