{"id":"W4408052556","doi":"10.1016/j.gene.2025.149370","title":"A multi-modal molecular characterization of the Philadelphia translocation featuring long read sequencing","year":2025,"lang":"en","type":"article","venue":"Gene","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hatch (Canada)","funders":"","keywords":"Biology; Chromosomal translocation; Computational biology; DNA sequencing; Genetics; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003150624,0.0003225023,0.0001263587,0.0008864065,0.0001279052,0.0002590898,0.0002078434,0.0004045423,0.001504445],"category_scores_gemma":[0.0007009706,0.0001191611,0.0001827762,0.0002694699,0.0001533236,0.000170807,0.0002455672,0.0002758198,0.000565314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000101133,"about_ca_system_score_gemma":0.00009533952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002004319,"about_ca_topic_score_gemma":0.0004160903,"domain_scores_codex":[0.9997461,0.00004111057,0.00001766444,0.00009983511,0.0000668526,0.00002835933],"domain_scores_gemma":[0.9996436,0.0001006594,0.00009187084,0.00004874057,0.00007639675,0.00003872345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001069499,0.00001677017,0.004093963,0.00004430673,0.00001239937,0.0002482775,0.00003740877,0.0002556177,0.9869615,0.0000804837,0.00007736551,0.008064994],"study_design_scores_gemma":[0.0000256011,0.0007386003,0.1227583,0.00003266677,0.0001006704,0.009000079,0.0001149416,0.01547042,0.8456132,0.0005637562,0.005551539,0.00003022271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9519354,0.0008917876,0.04309928,0.0001216757,0.00001892968,0.0001023794,0.001856574,0.0003851203,0.001588875],"genre_scores_gemma":[0.9312675,0.0003425569,0.06391151,0.0001076593,0.00001523362,0.0000885673,0.002655385,0.0000722837,0.001539363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504445,"threshold_uncertainty_score":0.005032897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0178448487776344,"score_gpt":0.2858683274282217,"score_spread":0.2680234786505873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}