{"id":"W4408067209","doi":"10.31083/fbl27638","title":"Polarized Tissue-Derived Macrophages Display Enhanced M2d Phenotype after Prolonged Stimulation with Adenosine A2A Receptor Agonist in the Presence of LPS","year":2025,"lang":"en","type":"article","venue":"Frontiers in Bioscience-Landmark","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Stimulation; Immune system; Innate immune system; Lipopolysaccharide; Macrophage; Cell biology; Agonist; Cancer research; Biology; Adenosine; Receptor; Immunology; Medicine; Endocrinology; Internal medicine; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001942224,0.0003073677,0.0002171424,0.0001577028,0.0001198203,0.000168449,0.00009568653,0.0002596296,0.001097216],"category_scores_gemma":[0.00008485538,0.00008685274,0.0002362948,0.0001393872,0.00014785,0.0001365824,0.0001595321,0.0004413377,0.0005264964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008066362,"about_ca_system_score_gemma":0.00009185461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001071956,"about_ca_topic_score_gemma":0.0001601701,"domain_scores_codex":[0.9998004,0.00004468859,0.00002374733,0.00003440349,0.00003532823,0.00006150773],"domain_scores_gemma":[0.9998826,0.00002515513,0.00002089927,0.00001601584,0.00002897882,0.0000263707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002306692,0.00003337906,0.0003222669,0.00004203287,0.000002819523,0.000100059,0.00002531197,0.00002319163,0.9986898,0.00001910063,0.00002968957,0.0004815746],"study_design_scores_gemma":[0.00003183649,0.001007295,0.01083685,0.00001392541,0.00002007341,0.000414089,0.0001012833,0.000356455,0.9851652,0.00005387839,0.001992174,0.000006866272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951066,0.0009030126,0.002193459,0.00008031671,0.00004387516,0.00003624255,0.0005092277,0.00002324783,0.00110402],"genre_scores_gemma":[0.9941134,0.0006465152,0.002455752,0.0001346677,0.00004552966,0.0001163312,0.0008536308,0.00001551863,0.001618661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001097216,"threshold_uncertainty_score":0.003670514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004468745822369071,"score_gpt":0.2318148428515439,"score_spread":0.2273460970291748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}