{"id":"W4408070166","doi":"10.1002/hbm.70171","title":"Association Between Single Nucleotide Polymorphisms in the Aquaporin‐4 Gene and Longitudinal Changes in White Matter Free Water and Cognitive Function in Non‐Demented Older Adults","year":2025,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Birth, Development, and Health","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Zhejiang Province; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; H. Lundbeck A/S; Servier; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; Eisai; National Institute on Aging; Alzheimer's Association; U.S. Department of Defense","keywords":"Single-nucleotide polymorphism; White matter; Association (psychology); Cognition; White (mutation); Genetics; Gene; Psychology; Longitudinal study; Neuroscience; Biology; Medicine; Genotype; Magnetic resonance imaging; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008972639,0.0001351513,0.0002507576,0.000443232,0.0001142192,0.0000352595,0.00004665076,0.000104593,0.00005008874],"category_scores_gemma":[0.00003883449,0.0001068317,0.00001448119,0.0002186161,0.00003078373,0.00008160524,0.00006264745,0.0002617739,0.000004895473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001531448,"about_ca_system_score_gemma":0.00001836502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002691191,"about_ca_topic_score_gemma":0.00557855,"domain_scores_codex":[0.9988161,0.0001108904,0.0003007506,0.0002941481,0.0001576214,0.0003204739],"domain_scores_gemma":[0.9996459,0.0001027634,0.00007834729,0.000101429,0.00003622966,0.00003533475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005399791,0.00006606998,0.9843869,0.0001732087,0.0000428852,0.00001324479,0.01034798,5.489745e-8,0.003125782,0.00004208121,0.0006382965,0.001109514],"study_design_scores_gemma":[0.003665574,0.00007594406,0.9920723,0.00118863,0.00003810517,0.000002031144,0.0016777,0.000009883441,0.0001789849,0.0009120884,0.00007160102,0.000107142],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801742,0.0001365695,0.00009783117,0.01788611,0.00005845443,0.0006531064,0.000004384445,0.00001324702,0.0009760906],"genre_scores_gemma":[0.994715,0.000102253,0.00004339133,0.004637895,0.0001152347,0.00004705742,0.0001005571,0.00001123278,0.0002273192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01454085,"threshold_uncertainty_score":0.435647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02571245583416439,"score_gpt":0.2640152397380979,"score_spread":0.2383027839039335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}