{"id":"W4408070166","doi":"10.1002/hbm.70171","title":"Association Between Single Nucleotide Polymorphisms in the Aquaporin‐4 Gene and Longitudinal Changes in White Matter Free Water and Cognitive Function in Non‐Demented Older Adults","year":2025,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Birth, Development, and Health","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Zhejiang Province; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; H. Lundbeck A/S; Servier; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; Eisai; National Institute on Aging; Alzheimer's Association; U.S. Department of Defense","keywords":"Single-nucleotide polymorphism; White matter; Association (psychology); Cognition; White (mutation); Genetics; Gene; Psychology; Longitudinal study; Neuroscience; Biology; Medicine; Genotype; Magnetic resonance imaging; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004439866,0.0003089519,0.0003069964,0.0003945241,0.0003655459,0.0003365107,0.0002394795,0.0004613142,0.001114067],"category_scores_gemma":[0.0009939498,0.0002489095,0.0003856518,0.0004256057,0.0001582839,0.0002748815,0.0002398142,0.0003874587,0.0001513142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308403,"about_ca_system_score_gemma":0.0001414318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003793212,"about_ca_topic_score_gemma":0.004227601,"domain_scores_codex":[0.9998542,0.00002621772,0.00002162138,0.00005480618,0.00002094745,0.00002224791],"domain_scores_gemma":[0.9995328,0.00008557914,0.000209297,0.00004356194,0.00006173454,0.00006696991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004434971,0.00007593592,0.9964756,0.00001234563,0.0001818031,0.0001494672,0.0001100812,0.00004335732,0.001336407,0.00001404352,0.00004556888,0.001111803],"study_design_scores_gemma":[0.000008894106,0.000129298,0.9993733,0.000001940789,0.00005172283,0.0001195425,0.00004773485,0.0000975438,0.00008566085,0.00002606692,0.00005642136,0.000001891145],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996545,0.0001074273,0.00004217704,0.00001263148,0.000002495317,0.000002358642,0.0001114748,0.000001664565,0.00006524962],"genre_scores_gemma":[0.9993278,0.00006497312,0.0000879275,0.00001657297,0.000006543405,0.000006574749,0.0002021344,0.000001197414,0.0002862266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003793212,"threshold_uncertainty_score":0.007542253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02571245583416439,"score_gpt":0.2640152397380979,"score_spread":0.2383027839039335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}