{"id":"W4408071195","doi":"10.1007/s11306-025-02233-3","title":"Identification of gangliosides and ceramides as biomarkers for mucopolysaccharidosis type II (hunter syndrome) through untargeted lipidomic analysis","year":2025,"lang":"en","type":"article","venue":"Metabolomics","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Takeda Pharmaceuticals International","keywords":"Hunter syndrome; Ceramide; Sphingolipid; Mucopolysaccharidosis; Chemistry; Lipid metabolism; Biochemistry; Lipidomics; Glycerophospholipid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000410567,0.0001712831,0.0006284425,0.00061939,0.0001475417,0.0000353852,0.0001559048,0.0001367202,0.0001290325],"category_scores_gemma":[0.0007208368,0.0001554534,0.000238395,0.001695268,0.0001877827,0.0001445551,0.0001100303,0.0001052282,0.00000788467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007515356,"about_ca_system_score_gemma":0.0001342763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003990364,"about_ca_topic_score_gemma":0.0000352947,"domain_scores_codex":[0.9985554,0.00006015313,0.000510911,0.0003957742,0.0002180675,0.0002596488],"domain_scores_gemma":[0.9988375,0.0001580031,0.0001598343,0.0004119127,0.0003694097,0.00006338074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004009853,0.0008701235,0.1607495,0.001210715,0.01967705,0.00001651325,0.001900483,0.00008139233,0.794188,0.006907635,0.003021431,0.007367251],"study_design_scores_gemma":[0.007398659,0.0008850832,0.2338336,0.000169004,0.0148821,0.00003829221,0.002659387,0.01556013,0.711494,0.007711215,0.004713411,0.0006551667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902483,0.004308687,0.003292825,0.0009502196,0.0002128422,0.0007162989,0.00004887831,0.00003848716,0.0001835253],"genre_scores_gemma":[0.9959996,0.0007924192,0.001700906,0.0002500369,0.00001961536,0.00005307049,0.00008138695,0.00002172863,0.001081286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08269407,"threshold_uncertainty_score":0.6339207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01593480287379605,"score_gpt":0.3185007950276783,"score_spread":0.3025659921538822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}