{"id":"W4408071880","doi":"10.1101/2025.02.25.640133","title":"Blood-Based Epigenetic Instability Linked to Human Aging and Disease","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"Epigenetics; Genome instability; Instability; Disease; Biology; Medicine; Genetics; Internal medicine; DNA; Physics; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003350532,0.0001307158,0.0002082962,0.0006218653,0.000131274,0.000318427,0.000101631,0.0001861926,0.001495219],"category_scores_gemma":[0.0005073966,0.00009843712,0.0001043282,0.0004998994,0.0001795632,0.0001337765,0.0002458758,0.0002341427,0.0002239235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001472701,"about_ca_system_score_gemma":0.0001222686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009456425,"about_ca_topic_score_gemma":0.0006919839,"domain_scores_codex":[0.9999001,0.00001982849,0.000006471511,0.00003839357,0.00002222965,0.00001307842],"domain_scores_gemma":[0.999808,0.00002975823,0.00007696236,0.00002732426,0.00002868929,0.00002924345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006704438,0.00003280587,0.2109993,0.0001363969,0.0001700503,0.0003340685,0.0003119423,0.000642655,0.7429149,0.001266979,0.000990264,0.04153021],"study_design_scores_gemma":[0.00001151779,0.0003065806,0.8645162,0.0000225292,0.000102059,0.001867893,0.0001373499,0.00222464,0.1226814,0.002849532,0.00526003,0.00002032403],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827982,0.004871591,0.008050435,0.000241126,0.0000369615,0.00001710342,0.001904934,0.0001362781,0.001943542],"genre_scores_gemma":[0.997113,0.0005422659,0.001096913,0.00005426039,0.00002173159,0.000006042828,0.0004089837,0.00001064703,0.0007460933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495219,"threshold_uncertainty_score":0.005001962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283918596517788,"score_gpt":0.24974644859072,"score_spread":0.2369072626255421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}