{"id":"W4408072885","doi":"10.1016/s0140-6736(25)00197-7","title":"Efficacy and safety of twice per year depemokimab in chronic rhinosinusitis with nasal polyps (ANCHOR-1 and ANCHOR-2): phase 3, randomised, double-blind, parallel trials","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"GlaxoSmithKline Biologicals; GlaxoSmithKline","keywords":"Chronic rhinosinusitis; Nasal polyps; Medicine; Double blind; Internal medicine; Surgery; Placebo; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009281892,0.0001710423,0.001007365,0.0001343407,0.00009714941,0.00003131459,0.0001052041,0.00008844645,0.0001294924],"category_scores_gemma":[0.0001213249,0.0001074423,0.00006260481,0.0002695586,0.0002111507,0.00007470628,0.00004642015,0.0002715394,0.000003743132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006472389,"about_ca_system_score_gemma":0.0002057044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001590587,"about_ca_topic_score_gemma":0.0001587507,"domain_scores_codex":[0.9986981,0.000180605,0.0004354262,0.0002554196,0.0001697447,0.0002607693],"domain_scores_gemma":[0.9988069,0.0005625981,0.000133777,0.0003660744,0.0000578443,0.00007279397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9289091,0.0006398894,0.0211698,0.0005088713,0.0008683517,0.0001222478,0.001245146,0.00003527282,0.01576145,0.004388283,0.01086403,0.01548754],"study_design_scores_gemma":[0.822167,0.0008477535,0.1706099,0.0008001016,0.0005624957,0.00009526989,0.00015061,0.0001017628,0.001578216,0.00008473246,0.002796969,0.0002052384],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890004,0.0042548,0.0002721293,0.002055452,0.00006498477,0.00154416,0.00008277161,0.00002985051,0.002695495],"genre_scores_gemma":[0.9973746,0.0009137712,0.0003847637,0.0004825963,0.0004043033,0.00006116896,0.00004883371,0.00001601773,0.0003139663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1494401,"threshold_uncertainty_score":0.438137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0498277248145131,"score_gpt":0.3596152747521201,"score_spread":0.309787549937607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}