{"id":"W4408072885","doi":"10.1016/s0140-6736(25)00197-7","title":"Efficacy and safety of twice per year depemokimab in chronic rhinosinusitis with nasal polyps (ANCHOR-1 and ANCHOR-2): phase 3, randomised, double-blind, parallel trials","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"GlaxoSmithKline Biologicals; GlaxoSmithKline","keywords":"Chronic rhinosinusitis; Nasal polyps; Medicine; Double blind; Internal medicine; Surgery; Placebo; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002822997,0.002288027,0.004116437,0.0006686125,0.000561974,0.001646722,0.001160865,0.003077306,0.005796816],"category_scores_gemma":[0.002097355,0.001121747,0.004313944,0.0005864246,0.001706155,0.001968311,0.0004733196,0.004149647,0.001361862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008116618,"about_ca_system_score_gemma":0.001097663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00130405,"about_ca_topic_score_gemma":0.002683436,"domain_scores_codex":[0.9990659,0.0004105947,0.00007892084,0.0001780278,0.00008463844,0.0001817678],"domain_scores_gemma":[0.9988388,0.0003682538,0.000288258,0.00008982208,0.00007859214,0.0003361895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9682852,0.003636896,0.0003925792,0.001551109,0.001350555,0.00003775466,0.00009444522,0.0002694757,0.002863885,0.0001238551,0.0007667377,0.02062749],"study_design_scores_gemma":[0.9543815,0.04332888,0.001038311,0.00005416267,0.0003810302,0.00002890819,0.00002335914,0.0001216686,0.0001790414,0.00008597763,0.0003610837,0.00001606328],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9577926,0.03272796,0.0009316639,0.0008871379,0.001163251,0.002891457,0.001422047,0.0001673893,0.00201658],"genre_scores_gemma":[0.9708312,0.01534755,0.002039109,0.001631066,0.000953184,0.004216273,0.001384798,0.00005364169,0.003543083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005796816,"threshold_uncertainty_score":0.01939231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0498277248145131,"score_gpt":0.3596152747521201,"score_spread":0.309787549937607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}