{"id":"W4408073032","doi":"10.1016/j.ijgc.2025.101755","title":"Circulating human papillomavirus DNA sequencing as a biomarker of response in advanced cervical cancer","year":2025,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Princess Margaret Cancer Foundation","keywords":"Medicine; Cervical cancer; Human papillomavirus; Biomarker; DNA sequencing; Oncology; DNA; Computational biology; Cancer research; Cancer; Virology; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001228746,0.000273741,0.0005631695,0.0009521196,0.0003068138,0.001108247,0.0002999545,0.0007480283,0.0009378832],"category_scores_gemma":[0.004765278,0.0001633234,0.0002279383,0.0007290808,0.00030243,0.0004893375,0.0002940729,0.0006222628,0.0001976846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004234992,"about_ca_system_score_gemma":0.0003630432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009873332,"about_ca_topic_score_gemma":0.0009908458,"domain_scores_codex":[0.9993318,0.0002272303,0.00004773019,0.0001310303,0.0001613677,0.0001007487],"domain_scores_gemma":[0.9980561,0.001078504,0.0002942772,0.00008530737,0.0002674976,0.0002184733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00284555,0.0002482236,0.9375892,0.0001068471,0.0001434486,0.0002852228,0.0003691885,0.0009656323,0.01840986,0.0001556907,0.000557669,0.03832348],"study_design_scores_gemma":[0.00006567516,0.003387729,0.97001,0.00007004933,0.0002086056,0.001279693,0.0009315252,0.009039154,0.0113576,0.0007518153,0.002867716,0.00003034063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967114,0.001529628,0.0003928464,0.0001702417,0.00005195089,0.00001603257,0.0002250325,0.0000254957,0.00087752],"genre_scores_gemma":[0.9987187,0.0002047184,0.0004243718,0.00009483718,0.00004163731,0.00001221666,0.0001856218,0.00000371213,0.0003141212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001228746,"threshold_uncertainty_score":0.006498337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06217829594589125,"score_gpt":0.4492171011232463,"score_spread":0.3870388051773551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}