{"id":"W4408091719","doi":"10.1172/jci177241","title":"CRISPR-mediated detection of Pneumocystis transcripts in bronchoalveolar, oropharyngeal, and serum specimens for Pneumocystis pneumonia diagnosis","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institute for Health and Care Research","keywords":"Pneumonia; Pneumocystis pneumonia; Pneumocystis carinii; Bronchoalveolar lavage; Microbiology; Medicine; Virology; Immunology; Pneumocystis jirovecii; Biology; Lung; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006580336,0.0004885484,0.0003796255,0.0005037416,0.0002554157,0.0004714974,0.0003105021,0.0005870702,0.001242981],"category_scores_gemma":[0.0008863465,0.0003361526,0.0003306744,0.0001706382,0.0004266253,0.0001823824,0.000400212,0.0006183282,0.0005740512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004195671,"about_ca_system_score_gemma":0.0004702039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006409972,"about_ca_topic_score_gemma":0.002372509,"domain_scores_codex":[0.9990076,0.0001268718,0.00009418312,0.0003219065,0.0003256448,0.0001237965],"domain_scores_gemma":[0.9993432,0.0001489292,0.0002079892,0.00008539034,0.0001343785,0.00008007357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005092443,0.00001786036,0.001801381,0.00006133825,0.000009469847,0.00004607897,0.00004120613,0.000133597,0.9951105,0.00008241025,0.0001177729,0.002527526],"study_design_scores_gemma":[0.00001028487,0.0003114283,0.008883024,0.00001988058,0.00003022925,0.0003212473,0.00005317662,0.002185471,0.9852324,0.00009484278,0.002842026,0.00001604683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.87457,0.001356823,0.1120545,0.0003159558,0.0001599744,0.0005381202,0.005444523,0.002240497,0.003319744],"genre_scores_gemma":[0.9199177,0.0007971996,0.07048234,0.0003792998,0.00002937764,0.0006644594,0.00360513,0.0001568672,0.003967644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242981,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0431005534668799,"score_gpt":0.3657655851118288,"score_spread":0.3226650316449489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}