{"id":"W4408093408","doi":"10.1016/j.isci.2025.112151","title":"Lymphopoiesis is attenuated upon hepatocyte-specific deletion of the cytochrome c oxidase assembly factor Sco1","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; University of Saskatchewan","keywords":"Cytochrome c oxidase; Hepatocyte; Chemistry; Cytochrome c; Cell biology; Biochemistry; Biology; Enzyme; Mitochondrion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009831526,0.0003083578,0.0001675062,0.0002709869,0.0001189826,0.0002249933,0.0001243448,0.0001609899,0.001674805],"category_scores_gemma":[0.0001410036,0.00009906541,0.0001037123,0.0001113629,0.0002832742,0.00009902866,0.0002290492,0.0003748144,0.0002816425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285186,"about_ca_system_score_gemma":0.0002037002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004405779,"about_ca_topic_score_gemma":0.0006955363,"domain_scores_codex":[0.9999079,0.00001360311,0.000008968034,0.00001859069,0.00002849226,0.00002250984],"domain_scores_gemma":[0.9998318,0.00002784421,0.00005433274,0.00001247777,0.00001016986,0.00006340031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001442904,0.0000174169,0.001002898,0.00001704354,0.000004507264,0.0002501947,0.00002188205,0.00004340888,0.9970585,0.00008756951,0.00003043229,0.001321787],"study_design_scores_gemma":[0.00005620149,0.0004835492,0.03514102,0.00001779669,0.00003812766,0.003899086,0.00008029468,0.001194248,0.9557956,0.0001045431,0.00318379,0.000005742132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974301,0.0003997969,0.001036046,0.00003923801,0.000007438325,0.000006288573,0.0001776003,0.0000857157,0.0008176402],"genre_scores_gemma":[0.9978503,0.000226253,0.0005157528,0.00001665498,0.000003510205,0.000007643193,0.0001819416,0.00001891994,0.00117908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001674805,"threshold_uncertainty_score":0.005602777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579754576011965,"score_gpt":0.2576132340064748,"score_spread":0.2418156882463552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}