{"id":"W4408098473","doi":"10.1021/acsnano.4c07503","title":"Host Immune Cell Membrane Deformability Governs the Uptake Route of Malaria-Derived Extracellular Vesicles","year":2025,"lang":"en","type":"article","venue":"ACS Nano","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Ústav organické chemie a biochemie Akademie věd České republiky; Canadian Institutes of Health Research; Azrieli Foundation; Israel Science Foundation; International Development Research Centre","keywords":"Vesicle; Immune system; Extracellular vesicles; Malaria; Cell biology; Extracellular; Plasmodium falciparum; Biophysics; Membrane; Chemistry; Host (biology); Biology; Immunology; Biochemistry; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005001277,0.000242701,0.0002475571,0.00003364952,0.0001480724,0.0000320251,0.0007348134,0.0002116105,0.00004652704],"category_scores_gemma":[0.0001941857,0.0001948111,0.0002429398,0.000204119,0.0002818564,0.00001068636,0.0003789911,0.0001525775,0.00001765141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003312006,"about_ca_system_score_gemma":0.0002030019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005846039,"about_ca_topic_score_gemma":0.00002444637,"domain_scores_codex":[0.9983578,0.0001337317,0.0005347991,0.0004184336,0.0002144844,0.000340805],"domain_scores_gemma":[0.9982373,0.0000443784,0.0002091987,0.001313561,0.0001240657,0.00007152835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001639534,0.0002278783,0.00192015,0.0001085199,0.00008652786,0.0000047163,0.00005953511,0.00004027753,0.9954684,0.0007216322,0.0002979386,0.0009004717],"study_design_scores_gemma":[0.0007452147,0.0000759542,0.01971633,0.000023346,0.00009497631,0.000003281122,0.0001730866,0.00004107727,0.9622853,0.000147522,0.01650868,0.0001852246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848682,0.01049915,0.0007551165,0.0004003319,0.0002389571,0.0004146695,0.00008874926,0.00002180874,0.002713069],"genre_scores_gemma":[0.9953464,0.00033448,0.0005246382,0.0001498406,0.0000685113,0.00002995148,0.0001031599,0.00002783455,0.003415197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0331831,"threshold_uncertainty_score":0.7944165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005758039382893396,"score_gpt":0.2210227997522951,"score_spread":0.2152647603694017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}