{"id":"W4408111462","doi":"10.1101/2025.03.01.25323122","title":"Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Lawson Health Research Institute; University of Toronto; Sunnybrook Health Science Centre; Western University","funders":"Canadian Institutes of Health Research","keywords":"In situ; Radiation therapy; Ductal carcinoma; Oncology; Internal medicine; Disease; Medicine; Biology; Geography; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000250985,0.000190464,0.0002734927,0.0008109489,0.0001765981,0.0004489922,0.0001714085,0.0002386161,0.001889786],"category_scores_gemma":[0.0007787128,0.00009213937,0.0001739313,0.0005265739,0.0002124311,0.0001533941,0.0002656836,0.0001942754,0.0002203073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001187661,"about_ca_system_score_gemma":0.00008448324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005574094,"about_ca_topic_score_gemma":0.0007838734,"domain_scores_codex":[0.9998442,0.00002323358,0.00002002276,0.00006021828,0.00002765827,0.00002464359],"domain_scores_gemma":[0.9995127,0.0001389011,0.0001817704,0.00004542482,0.00005902643,0.0000621539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000486344,0.00003377941,0.9585673,0.00007720445,0.0001845943,0.0004555132,0.00008118481,0.0003000985,0.03135906,0.00006098569,0.0001570736,0.00823687],"study_design_scores_gemma":[0.000006189693,0.00007557667,0.9929273,0.00001027302,0.00008179825,0.002452176,0.0001170188,0.0005408744,0.003240068,0.0001190993,0.000424905,0.000004613311],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988557,0.0003333779,0.0001518058,0.00001309169,0.000001508847,0.000003419399,0.000396277,0.000006694404,0.0002380237],"genre_scores_gemma":[0.9993344,0.00008932714,0.00008543586,0.000007919129,0.00000303693,0.000003387465,0.0003759337,0.000003346589,0.00009721952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001889786,"threshold_uncertainty_score":0.006321967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007075292432242291,"score_gpt":0.2483700387494072,"score_spread":0.2412947463171649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}