{"id":"W4408123725","doi":"10.1186/s12967-025-06253-4","title":"Analysis of the measurements used as potency tests for the 31 US FDA-approved cell therapy products","year":2025,"lang":"en","type":"review","venue":"Journal of Translational Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Potency; Medicine; Pharmacology; Drug approval; Medical physics; Drug; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02697809,0.001255584,0.000948113,0.007077347,0.0007261609,0.002599064,0.0008391084,0.0008734966,0.003179718],"category_scores_gemma":[0.05616113,0.0005223911,0.001278413,0.007882861,0.001335839,0.001126673,0.00140909,0.00193939,0.002163988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00210923,"about_ca_system_score_gemma":0.002282266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003504876,"about_ca_topic_score_gemma":0.003314336,"domain_scores_codex":[0.9549877,0.007164706,0.004469805,0.003019636,0.02940831,0.000949848],"domain_scores_gemma":[0.9248286,0.03558948,0.01358931,0.004654145,0.02049883,0.0008395368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002446108,0.000834212,0.4028214,0.004729557,0.001077618,0.001126937,0.001994467,0.00429582,0.08435076,0.003630205,0.0202956,0.4723973],"study_design_scores_gemma":[0.0001110782,0.00387349,0.5839126,0.001136786,0.001471316,0.004485624,0.002526812,0.00883825,0.2413426,0.00191075,0.1500853,0.0003053306],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7415598,0.04457231,0.08790023,0.00186608,0.001039695,0.003855355,0.04604224,0.002608313,0.07055606],"genre_scores_gemma":[0.9071227,0.01121097,0.04899179,0.001513378,0.0002137037,0.001983929,0.02139483,0.0005725989,0.006996199],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.02697809,"threshold_uncertainty_score":0.1426755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1979750245329355,"score_gpt":0.4324895607580021,"score_spread":0.2345145362250666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}