{"id":"W4408128329","doi":"10.1093/jncics/pkaf025","title":"Multi-gene risk score for prediction of clinical outcomes in treatment-naïve metastatic castrate-resistant prostate cancer","year":2025,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute","keywords":"Medicine; Prostate cancer; Oncology; Internal medicine; Cancer; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000402715,0.0003072397,0.001042439,0.0003158211,0.00009567324,0.00002013418,0.0001096472,0.000110609,0.0001022846],"category_scores_gemma":[0.0001220691,0.0002122791,0.0003601667,0.0004935637,0.0001782568,0.00009436996,0.00003413509,0.0002543624,0.000002817465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001021376,"about_ca_system_score_gemma":0.001914085,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01167229,"about_ca_topic_score_gemma":0.01365677,"domain_scores_codex":[0.9974995,0.0001044963,0.0009578922,0.0005831745,0.000294791,0.0005602013],"domain_scores_gemma":[0.9987773,0.0002179039,0.0002991555,0.0003868677,0.0001566398,0.000162157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005431431,0.001107671,0.9753459,0.0003638622,0.001498608,0.00005783917,0.0003292915,0.0001206684,0.002218965,0.00003988188,0.0003526389,0.01313325],"study_design_scores_gemma":[0.02209304,0.001858833,0.9383426,0.0004127609,0.0009207967,0.000001870208,0.0002180769,0.001685142,0.03286928,0.000230688,0.001211301,0.0001555619],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823661,0.005946626,0.000133839,0.002624098,0.0008842133,0.003313458,0.004507972,0.00005213176,0.0001714997],"genre_scores_gemma":[0.9728824,0.01285231,0.001282316,0.00009408201,0.0001527694,0.00215133,0.0001521425,0.00004106229,0.01039157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03700325,"threshold_uncertainty_score":0.994909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1114796726366881,"score_gpt":0.4476404803388036,"score_spread":0.3361608077021155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}