{"id":"W4408138392","doi":"10.3389/ti.2025.14171","title":"Donor and Recipient Polygenic Risk Scores Influence Kidney Transplant Function","year":2025,"lang":"en","type":"article","venue":"Transplant International","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; Canadian Society of Nephrology; Impact; McMaster University; Population Health Research Institute","funders":"National Institute of Allergy and Infectious Diseases; European Commission; King's College London; Astellas Pharma; Guy's and St Thomas' Charity; Wellcome Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Medical Research Council; Sanofi","keywords":"Medicine; Kidney transplantation; Internal medicine; Renal function; Kidney transplant; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001527908,0.0003138444,0.000299031,0.0003939036,0.0002418781,0.0006514908,0.0002412641,0.0002308888,0.002085818],"category_scores_gemma":[0.003443583,0.0001468244,0.0006457844,0.0005660065,0.0003563462,0.0003640318,0.0004533527,0.0004746583,0.0001497741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001614385,"about_ca_system_score_gemma":0.0003146467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002450634,"about_ca_topic_score_gemma":0.003063599,"domain_scores_codex":[0.998923,0.0006143152,0.00005775877,0.0001597541,0.0001061113,0.0001390663],"domain_scores_gemma":[0.9971375,0.001061575,0.0008507858,0.0004408629,0.0001191634,0.0003902033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001041863,0.00001827365,0.9950464,0.00000606673,0.000227044,0.00005886728,0.00004142506,0.0003395862,0.0006433557,0.0001394153,0.00007267746,0.0033027],"study_design_scores_gemma":[0.000002053497,0.00003572457,0.99822,0.000002431665,0.00006540294,0.0001054478,0.00002380291,0.001102754,0.0001183964,0.0002280411,0.00009252181,0.000003337856],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977101,0.0001571294,0.001350301,0.00008334866,0.00000684054,0.000004744915,0.000189374,0.00001057193,0.0004874777],"genre_scores_gemma":[0.9996182,0.0000302869,0.0001552258,0.000007497406,0.000005429345,0.000001574662,0.00007339269,0.000002000291,0.0001062731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002450634,"threshold_uncertainty_score":0.008080423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009660565076361038,"score_gpt":0.2713737687366616,"score_spread":0.2617132036603006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}