{"id":"W4408138392","doi":"10.3389/ti.2025.14171","title":"Donor and Recipient Polygenic Risk Scores Influence Kidney Transplant Function","year":2025,"lang":"en","type":"article","venue":"Transplant International","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; Canadian Society of Nephrology; Impact; McMaster University; Population Health Research Institute","funders":"National Institute of Allergy and Infectious Diseases; European Commission; King's College London; Astellas Pharma; Guy's and St Thomas' Charity; Wellcome Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Medical Research Council; Sanofi","keywords":"Medicine; Kidney transplantation; Internal medicine; Renal function; Kidney transplant; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009893523,0.0001906181,0.0002133913,0.0002472015,0.0001042676,0.0000367104,0.00009546301,0.00008250769,0.0001740811],"category_scores_gemma":[0.0000140961,0.0001525439,0.0001163483,0.0001290565,0.00006012563,0.0001354382,0.00000590195,0.0001843877,0.00003494122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005698506,"about_ca_system_score_gemma":0.00009186588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002476869,"about_ca_topic_score_gemma":0.00005015571,"domain_scores_codex":[0.998839,0.00003048882,0.0003315886,0.00032103,0.0002921905,0.0001857137],"domain_scores_gemma":[0.9994701,0.00009067514,0.00006406771,0.0001368162,0.00007482163,0.0001635496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002809878,0.0002055878,0.983745,0.0002295746,0.0009774554,0.0001041851,0.0003788425,0.0000709853,0.003171652,0.004380861,0.0001170232,0.003808941],"study_design_scores_gemma":[0.004876318,0.0001797148,0.985895,0.001397741,0.0007959315,0.0002127412,0.0000151081,0.0004562913,0.002609257,0.000380788,0.003021908,0.0001591776],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984162,0.0002476113,0.00661322,0.001591848,0.0007104321,0.0003545931,0.0008579277,0.00009033646,0.005371972],"genre_scores_gemma":[0.9926486,0.003265899,0.0004378287,0.001286908,0.00005172508,0.00003624766,0.0005628111,0.00001142293,0.001698539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00848656,"threshold_uncertainty_score":0.6220559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009660565076361038,"score_gpt":0.2713737687366616,"score_spread":0.2617132036603006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}