{"id":"W4408140745","doi":"10.1093/ibd/izaf036","title":"Efficacy and Safety of Etrasimod in Patients With Moderately to Severely Active Ulcerative Colitis Stratified by Baseline Modified Mayo Score: A Post Hoc Analysis From the Phase 3 ELEVATE UC Clinical Program","year":2025,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Pfizer","keywords":"Medicine; Ulcerative colitis; Internal medicine; Post-hoc analysis; Placebo; Adverse effect; Clinical trial; Gastroenterology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005805492,0.0009160994,0.002579002,0.0004171762,0.000353032,0.0006874222,0.0004821233,0.0005252381,0.002217574],"category_scores_gemma":[0.003504189,0.0003285871,0.003686057,0.0004132881,0.0004664619,0.0006176399,0.0005299511,0.001217244,0.0002507391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004968863,"about_ca_system_score_gemma":0.000814151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004498659,"about_ca_topic_score_gemma":0.001031307,"domain_scores_codex":[0.9974136,0.001598718,0.0002038903,0.0003033788,0.0002466885,0.0002337171],"domain_scores_gemma":[0.9955141,0.002145796,0.0009894228,0.0004973104,0.000329643,0.0005236865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8935412,0.003929682,0.07333836,0.0003119853,0.00820717,0.0001284999,0.0001068813,0.001058865,0.005606479,0.00003911648,0.0007516129,0.0129802],"study_design_scores_gemma":[0.1136598,0.3536094,0.5116174,0.00005216483,0.01186775,0.0003514862,0.0001897398,0.003474813,0.003334899,0.0001617737,0.00159046,0.00009030516],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981177,0.0005590392,0.0002117158,0.00004517062,0.00002025784,0.000213066,0.000496886,0.00001109941,0.0003251696],"genre_scores_gemma":[0.9980251,0.0001443224,0.0002882433,0.00007393379,0.00005245156,0.0002180795,0.0009331666,0.00000634964,0.0002583759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005805492,"threshold_uncertainty_score":0.03070277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00877209913828546,"score_gpt":0.2834212807223894,"score_spread":0.2746491815841039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}