{"id":"W4408142268","doi":"10.2139/ssrn.5152849","title":"BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Care Foundation","funders":"","keywords":"Dolutegravir; Medicine; Clinical trial; Antiretroviral therapy; Tenofovir; Human immunodeficiency virus (HIV); Oncology; Internal medicine; Viral load; Family medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005922411,0.003402001,0.005993253,0.0008266053,0.0006304435,0.001801846,0.001560186,0.003678794,0.02370171],"category_scores_gemma":[0.006515582,0.001014163,0.002696961,0.0005161635,0.002365335,0.002671677,0.001116192,0.0042185,0.002052492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008475279,"about_ca_system_score_gemma":0.001415034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007174778,"about_ca_topic_score_gemma":0.001377997,"domain_scores_codex":[0.9965119,0.002459685,0.0001824441,0.0004260967,0.0001259075,0.0002940206],"domain_scores_gemma":[0.9970242,0.001386193,0.0006607882,0.0002772823,0.0001261276,0.000525397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9931636,0.00208699,0.00008058191,0.0003936641,0.000380316,0.00001999729,0.00002878906,0.000117006,0.0005247046,0.0001881715,0.0001779115,0.002838218],"study_design_scores_gemma":[0.97828,0.02078661,0.0001638498,0.00001948396,0.0001636527,0.000006899097,0.000009249072,0.0001698479,0.00005919245,0.0001731172,0.0001599414,0.000008115009],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.945998,0.005966533,0.004302092,0.00197585,0.002899029,0.03017513,0.002282398,0.0005947572,0.005806133],"genre_scores_gemma":[0.9078335,0.002846997,0.01126288,0.002736691,0.001755577,0.05584746,0.001094169,0.0001028729,0.01651985],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.02370171,"threshold_uncertainty_score":0.07929009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06562715062899956,"score_gpt":0.3907395387106574,"score_spread":0.3251123880816579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}