{"id":"W4408142346","doi":"10.1093/nar/gkaf105","title":"Packaged delivery of CRISPR–Cas9 ribonucleoproteins accelerates genome editing","year":2025,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Emerson Collective; Howard Hughes Medical Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; CRISPR; Genome editing; Ribonucleoprotein; Cas9; Genetics; Computational biology; Guide RNA; Genome; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004792387,0.000370927,0.0004724156,0.0002302603,0.000152194,0.0007329338,0.0003298696,0.0006049749,0.0009942017],"category_scores_gemma":[0.0007186757,0.000236245,0.0003620728,0.0001554902,0.000399144,0.0003721951,0.0003796941,0.001067952,0.0004827855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005560862,"about_ca_system_score_gemma":0.0004156842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005742052,"about_ca_topic_score_gemma":0.0008640712,"domain_scores_codex":[0.9994356,0.00008715867,0.00005181112,0.000156289,0.0002126964,0.0000564203],"domain_scores_gemma":[0.9996262,0.0001258341,0.00008570533,0.00006433483,0.00005203459,0.00004588766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002921939,0.00002478028,0.0001190264,0.00003733868,0.000008505996,0.00002184322,0.00001317548,0.0004909592,0.9954164,0.0002451309,0.00005745872,0.003536134],"study_design_scores_gemma":[0.000004501559,0.0001346608,0.0006493608,0.000003516351,0.000007009512,0.00005022132,0.000004801161,0.00237855,0.9950853,0.00005793745,0.001618688,0.000005440303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7687565,0.001742455,0.2223448,0.0002948878,0.0001660423,0.0001718203,0.0005451374,0.001565166,0.00441327],"genre_scores_gemma":[0.9194236,0.0008406523,0.07381716,0.0001352213,0.00002027105,0.00008757902,0.0007175691,0.0002389117,0.004718941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009942017,"threshold_uncertainty_score":0.004034698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02492320858400664,"score_gpt":0.3653655227046351,"score_spread":0.3404423141206284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}