{"id":"W4408144109","doi":"10.1016/j.jtho.2024.12.021","title":"Predictive Biomarker for SCLC Therapeutics: A Broken Promise or a Complex Disease With Missing Links","year":2025,"lang":"en","type":"editorial","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Cancer Foundation; University of Alberta","funders":"","keywords":"Medicine; Biomarker; Disease; Biomarker discovery; Oncology; Internal medicine; Proteomics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001400707,0.0004567589,0.001872581,0.0006307914,0.0002127045,0.00006541151,0.0004363414,0.0009919812,0.00007139021],"category_scores_gemma":[0.003660798,0.0002672649,0.0004272033,0.0003373021,0.0004894713,0.0001195577,0.000170279,0.002482314,0.000002033062],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002188076,"about_ca_system_score_gemma":0.02014515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001301313,"about_ca_topic_score_gemma":0.00003858779,"domain_scores_codex":[0.9963511,0.0004008436,0.0009406519,0.000453478,0.001259785,0.000594196],"domain_scores_gemma":[0.9909472,0.003626017,0.001263382,0.0004042253,0.003245357,0.000513833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1549843,0.0005810346,0.0001485665,0.002905503,0.004489651,0.001182557,0.0003960737,0.00000262791,0.000137272,8.426038e-7,0.771718,0.06345359],"study_design_scores_gemma":[0.005729765,0.0115664,0.001097159,0.004887516,0.006220151,0.0001200541,0.0002286558,0.0002366828,0.00003456671,0.0001567686,0.9694757,0.0002465476],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.001237189,0.02030603,0.01016685,0.07415873,0.8765535,0.01037171,0.002330516,0.0001625763,0.004712951],"genre_scores_gemma":[0.002377115,0.003516425,0.02187149,0.001457544,0.9519427,0.0005169444,0.0002703708,0.0002101489,0.0178372],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.1977577,"threshold_uncertainty_score":0.9999779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07089036606738772,"score_gpt":0.5033168943564978,"score_spread":0.4324265282891101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}