{"id":"W4408144109","doi":"10.1016/j.jtho.2024.12.021","title":"Predictive Biomarker for SCLC Therapeutics: A Broken Promise or a Complex Disease With Missing Links","year":2025,"lang":"en","type":"editorial","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Cancer Foundation; University of Alberta","funders":"","keywords":"Medicine; Biomarker; Disease; Biomarker discovery; Oncology; Internal medicine; Proteomics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0201756,0.005150694,0.009022999,0.004679883,0.003135991,0.01102415,0.005599074,0.02208542,0.01091183],"category_scores_gemma":[0.04826555,0.001898282,0.005000217,0.001932459,0.003604898,0.006502248,0.002016736,0.03076956,0.00886658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003925619,"about_ca_system_score_gemma":0.005054974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001762708,"about_ca_topic_score_gemma":0.003939991,"domain_scores_codex":[0.9903373,0.002382355,0.001589525,0.00102822,0.004134628,0.0005280845],"domain_scores_gemma":[0.9354457,0.03569139,0.002820776,0.001386763,0.01850382,0.006151642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001543293,0.00002143741,0.00004743301,0.0005940778,0.00009312715,0.000118736,0.00001073159,0.00003410245,0.00007060418,0.000415191,0.9898825,0.008557724],"study_design_scores_gemma":[0.0006009809,0.0001927167,0.0007540712,0.002687698,0.0007633096,0.000679363,0.0001059213,0.0008792407,0.0003118548,0.004769796,0.9881523,0.0001028416],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00002967831,0.006880407,0.000149154,0.02595016,0.9663633,0.00001865852,0.00005135395,0.00004851312,0.0005087417],"genre_scores_gemma":[0.0002314614,0.004515177,0.0001286755,0.01580701,0.9770756,0.00001655546,0.00002566822,0.00001907733,0.002180754],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.02208542,"threshold_uncertainty_score":0.1067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07089036606738772,"score_gpt":0.5033168943564978,"score_spread":0.4324265282891101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}