{"id":"W4408148841","doi":"10.1158/1055-9965.epi-24-1442","title":"Association of Inherited Genetic Variants with Multiple Primary Melanoma","year":2025,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control","funders":"National Institute of Environmental Health Sciences; Melanoma Centre of Research Excellence; National Cancer Institute","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Odds ratio; Minor allele frequency; Genetic association; Medicine; Allele; Population; Oncology; Genetics; Confidence interval; Internal medicine; Biology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009066681,0.0004284912,0.0004531047,0.000686628,0.0002846341,0.0005546657,0.0003480041,0.0003556227,0.003651392],"category_scores_gemma":[0.003049463,0.0001880565,0.0008691794,0.0009918965,0.0003342824,0.0001764047,0.0004693177,0.0006803728,0.000204246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218944,"about_ca_system_score_gemma":0.0002704307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002022647,"about_ca_topic_score_gemma":0.002309227,"domain_scores_codex":[0.9991847,0.0001904277,0.00008040234,0.0003204188,0.00014796,0.00007616873],"domain_scores_gemma":[0.9971281,0.0009128035,0.001312602,0.0002841946,0.0001690879,0.0001932406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005179468,0.00002837288,0.985179,0.0001172812,0.001496809,0.0008970377,0.00004723334,0.0003863857,0.004356975,0.0001524964,0.0002091128,0.006611293],"study_design_scores_gemma":[0.00003389796,0.0001197315,0.9930705,0.0000328935,0.0008850396,0.003156517,0.00003494119,0.0008197255,0.001022368,0.0003912999,0.000426325,0.0000067745],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941494,0.002835474,0.001416844,0.0001805994,0.0000225235,0.000009901823,0.0006415084,0.0000463888,0.0006973164],"genre_scores_gemma":[0.9989279,0.0003307318,0.0003960482,0.00002386916,0.00001492329,0.000003525624,0.0001831552,0.000006528833,0.0001133322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003651392,"threshold_uncertainty_score":0.01221508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02066271710808137,"score_gpt":0.3071123211226255,"score_spread":0.2864496040145442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}