{"id":"W4408150180","doi":"10.1016/j.nbd.2025.106862","title":"Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration","year":2025,"lang":"en","type":"review","venue":"Neurobiology of Disease","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Science Foundation of Hebei Province","keywords":"Neurodegeneration; Senescence; Mitochondrion; Neuroscience; Biology; Cell biology; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004560863,0.000790987,0.0009583918,0.001814348,0.0003861275,0.00106251,0.0007391738,0.001239004,0.002551366],"category_scores_gemma":[0.0004855944,0.0002185084,0.0003866669,0.001751921,0.0006188774,0.001818257,0.0009204513,0.001941057,0.001618481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009305395,"about_ca_system_score_gemma":0.001149114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009071663,"about_ca_topic_score_gemma":0.001651758,"domain_scores_codex":[0.9998475,0.00003199986,0.00001985072,0.00002511281,0.00005502421,0.00002031057],"domain_scores_gemma":[0.9998227,0.00006068523,0.00002442164,0.000006234592,0.00006045296,0.00002551492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001071234,0.00005098668,0.0001907443,0.0157852,0.00008782302,0.0003512911,0.000142913,0.0004443053,0.004868467,0.01121921,0.03371785,0.9330339],"study_design_scores_gemma":[0.00001133797,0.00008156904,0.0007722662,0.002951681,0.00006383065,0.001459769,0.00009327709,0.00008900274,0.0007379793,0.00554164,0.9881781,0.00001948014],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009504805,0.998633,0.0001398502,0.0003299981,0.0002082193,0.000002317811,0.000008579144,0.000007167706,0.0005759046],"genre_scores_gemma":[0.0007451278,0.9982898,0.0001511935,0.0001656903,0.0001533972,0.000003607056,0.00001814795,0.000001338051,0.0004717325],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002551366,"threshold_uncertainty_score":0.008535206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899917151989763,"score_gpt":0.3075769014722982,"score_spread":0.2885777299524006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}