{"id":"W4408150859","doi":"10.1073/pnas.2414748122","title":"Effects of binding partners on thermal reversion rates of photoswitchable molecules","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Toronto","funders":"RES’EAU-WaterNET; Natural Sciences and Engineering Research Council of Canada","keywords":"Reversion; Optogenetics; Molecule; Chemistry; Transition (genetics); Function (biology); Biophysics; Chemical physics; Biology; Cell biology; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001169798,0.0006086796,0.0005312013,0.0003624729,0.0003973178,0.0009037348,0.0005891895,0.0003681995,0.002823609],"category_scores_gemma":[0.003737083,0.0003500135,0.0003580903,0.000374308,0.0006953395,0.0009941264,0.0005429799,0.001007631,0.0003911147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006117125,"about_ca_system_score_gemma":0.0002665056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043731,"about_ca_topic_score_gemma":0.0008945815,"domain_scores_codex":[0.9990839,0.0001645284,0.00007612263,0.0002011495,0.0003166678,0.000157688],"domain_scores_gemma":[0.9975324,0.001641896,0.0002756832,0.0001972456,0.0001686569,0.0001842115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000733663,0.0002771681,0.00201901,0.0001522202,0.00006628393,0.0001721644,0.0001805866,0.006184789,0.9773504,0.001848231,0.0001790081,0.01083649],"study_design_scores_gemma":[0.00001759143,0.0004485766,0.002993822,0.00001092867,0.0000379667,0.0000773772,0.00007709862,0.0197304,0.9755695,0.000367537,0.0006394905,0.00002969388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912799,0.0009548494,0.004033528,0.00007702701,0.00003140248,0.00004843391,0.0001072337,0.0001168599,0.003350673],"genre_scores_gemma":[0.9976362,0.0003690136,0.001153287,0.00003995028,0.000005845755,0.000047197,0.00009169213,0.0000326509,0.000624194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002823609,"threshold_uncertainty_score":0.009445965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05850695818944463,"score_gpt":0.377880866496378,"score_spread":0.3193739083069334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}