{"id":"W4408161524","doi":"10.1002/jimd.70018","title":"Altered Fibroblast Glutamine Metabolism Is Linked to the Severity of Cardiac Dysfunction in <scp>DCMA</scp> , a Mitochondrial Cardiomyopathy","year":2025,"lang":"en","type":"article","venue":"Journal of Inherited Metabolic Disease","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Children's Hospital; Alberta Hip and Knee Clinic; University of Calgary","funders":"Alberta Children's Hospital Foundation; National Human Genome Research Institute; Canada Foundation for Innovation; International Microbiome Centre, University of Calgary; Children's Cardiomyopathy Foundation","keywords":"Glutamine; Cardiomyopathy; Internal medicine; Mitochondrion; Endocrinology; Medicine; Biology; Heart failure; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416278,0.0003457389,0.0002832451,0.0008431342,0.0002860269,0.0003474621,0.0001238428,0.0003986575,0.001071294],"category_scores_gemma":[0.0003959179,0.0001420523,0.0001662764,0.000334726,0.0003261452,0.0001329281,0.0002178456,0.0004059045,0.0002129176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001804215,"about_ca_system_score_gemma":0.00009899326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123297,"about_ca_topic_score_gemma":0.001373286,"domain_scores_codex":[0.9998259,0.00003321759,0.00002462852,0.00004873956,0.00004813967,0.00001939415],"domain_scores_gemma":[0.9996767,0.00007810774,0.00009629477,0.00002738541,0.0000331657,0.0000883465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008945512,0.0001000967,0.07746624,0.00003907707,0.00004137126,0.002319749,0.0001410604,0.0001311417,0.9153704,0.00007904904,0.0001087243,0.003308503],"study_design_scores_gemma":[0.00004049619,0.001060686,0.8005372,0.00001668401,0.00005421046,0.01735108,0.0002600774,0.001371379,0.1781586,0.0002099185,0.0009160596,0.00002359787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998757,0.0002501243,0.0004193638,0.00002622734,0.000006496912,0.000008824212,0.0002415495,0.00001075438,0.0002795804],"genre_scores_gemma":[0.9990275,0.0001383097,0.000396465,0.0000183739,0.000004385377,0.000009528708,0.0002156804,0.000003359206,0.0001863544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001123297,"threshold_uncertainty_score":0.003583848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007929549461824848,"score_gpt":0.2432034322378165,"score_spread":0.2352738827759917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}