{"id":"W4408164481","doi":"10.3390/biomedicines13030637","title":"Rapid In Vivo Screening of Monoclonal Antibody Cocktails Using Hydrodynamic Delivery of DNA-Encoded Modified Antibodies","year":2025,"lang":"en","type":"article","venue":"Biomedicines","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Sinai Health System; University of Toronto; Health Sciences Centre; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Monoclonal antibody; In vivo; Antibody; Plasmid; Recombinant DNA; Transfection; In vitro; Biology; Molecular biology; DNA; Chemistry; Immunology; Gene; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005973527,0.0005607196,0.0002831697,0.0005186707,0.0001256098,0.0003418812,0.0002719266,0.0004741826,0.001045305],"category_scores_gemma":[0.0002805031,0.0002053281,0.0002890724,0.0002264562,0.0002838912,0.0002312662,0.0002886563,0.0006523618,0.0003607302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004577606,"about_ca_system_score_gemma":0.0002176801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002400198,"about_ca_topic_score_gemma":0.0003275134,"domain_scores_codex":[0.9996045,0.00007998413,0.00002657001,0.00008760361,0.0001448187,0.00005657339],"domain_scores_gemma":[0.9998131,0.00005106623,0.0000635738,0.00001528693,0.00002788592,0.00002917123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002965055,0.00002262168,0.00005408989,0.00001802187,0.000003638757,0.00001113726,0.000004438491,0.00007904625,0.998826,0.00004500309,0.00002403882,0.0008823282],"study_design_scores_gemma":[0.00001503391,0.0002720905,0.0002969828,0.000002388981,0.000009118091,0.00005716449,0.000002349092,0.001015826,0.9975553,0.00001547529,0.0007556843,0.000002540155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8770666,0.002148159,0.1163901,0.0002219218,0.00008497982,0.0005785631,0.0005003862,0.000451319,0.002557845],"genre_scores_gemma":[0.9122229,0.001831039,0.08071408,0.0001441528,0.00003710736,0.0003259545,0.0009504636,0.00007188498,0.003702414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001045305,"threshold_uncertainty_score":0.003496945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04377021080610815,"score_gpt":0.3520052164442442,"score_spread":0.308235005638136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}