{"id":"W4408167162","doi":"10.1016/j.radonc.2025.110831","title":"Opioid therapy vs. Multimodal analgesia in head and neck cancer (OPTIMAL-HN): Results of a randomized clinical trial","year":2025,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"Oral health in cancer treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Ottawa Hospital; University of Ottawa; Western University","funders":"Western University; Physicians' Services Incorporated Foundation","keywords":"Medicine; Pregabalin; Opioid; Randomized controlled trial; Clinical endpoint; Analgesic; Confidence interval; Anesthesia; Acetaminophen; Multimodal therapy; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006783584,0.001206006,0.003903907,0.0004288189,0.000429761,0.001239112,0.001020267,0.001826061,0.006643359],"category_scores_gemma":[0.006923636,0.0005412545,0.002896033,0.0004848382,0.001368687,0.001223153,0.0006186288,0.001891378,0.000547835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009839301,"about_ca_system_score_gemma":0.001591105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005698088,"about_ca_topic_score_gemma":0.001178881,"domain_scores_codex":[0.9964497,0.002496032,0.0003065212,0.0003362139,0.0001769819,0.0002346162],"domain_scores_gemma":[0.9952024,0.002620123,0.00107828,0.0003249113,0.0002469429,0.000527381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9871344,0.002690091,0.0003746528,0.001136306,0.001035905,0.00001510592,0.0000233767,0.0001859864,0.00029548,0.0000781081,0.0002514131,0.006779152],"study_design_scores_gemma":[0.9639302,0.0332674,0.0007607301,0.0001163754,0.00104837,0.0000136238,0.00001466777,0.0002912047,0.00008913416,0.0001778453,0.000279895,0.00001044202],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961623,0.02183603,0.001286659,0.001560101,0.001218558,0.008489788,0.001350629,0.00007754021,0.002557766],"genre_scores_gemma":[0.9763845,0.006733612,0.002767736,0.001605003,0.001181283,0.008868597,0.0008579216,0.0000226679,0.00157871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006783584,"threshold_uncertainty_score":0.0358755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05578204608479366,"score_gpt":0.4638276761580648,"score_spread":0.4080456300732711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}